Abstract

Studies on the genetics of viral leukemogenesis in wild mice have revealed that these mice differ substantially from the inbred strains. Analysis of a variety of feral mouse populations have shown that almost all lack ecotropic-MuLV related sequences. MuLVs with ecotropic host range have been isolated from M. hortulanus, M. m. castaneus and M. m. molossinus. Data from Southern blot hybridizations indicate that most of these viruses differ from ecotropic MuLVs of inbred mice in their hybridization properties and internal restriction maps. Cells of most wild mice also differ from inbred mice in their susceptibility to exogenous infection. Most lack the restriction defined by the known alleles at the Fv-1 locus. Genetic crosses demonstrated that 2 of these mice, M spretus and M. praetextus, carry the rare resistance allele at Fv-2. These mice also differ from laboratory mice in their susceptibility to xenotropic MuLVs. This trait is controlled by a single chromosome 1 locus, designated Sxv, which may represent a wild mouse polymorphism of the MCF-MuLV receptor locus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000300-04
Application #
4688452
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Yan, Yuhe; Buckler-White, Alicia; Wollenberg, Kurt et al. (2009) Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus. Proc Natl Acad Sci U S A 106:3259-63
Yan, Yuhe; Kozak, Christine A (2008) Novel postentry resistance to AKV ecotropic mouse gammaretroviruses in the African pygmy mouse, Mus minutoides. J Virol 82:6120-9
Yan, Yuhe; Knoper, Ryan C; Kozak, Christine A (2007) Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry. J Virol 81:10550-7
Tanaka, Kazuhiro; Tsumaki, Noriyuki; Kozak, Christine A et al. (2006) A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha2(XI) collage gene. Mol Cell Biol 26:8215-6
Wu, Tiyun; Yan, Yuhe; Kozak, Christine A (2005) Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses. J Virol 79:9677-84
Lee, Suk Keun; Kim, Yeon Sook; Lee, Sang Shin et al. (2004) Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25. Genomics 83:243-53
Jung, Yong Tae; Wu, Tiyun; Kozak, Christine A (2003) Characterization of recombinant nonecotropic murine leukemia viruses from the wild mouse species Mus spretus. J Virol 77:12773-81
Jung, Yong Tae; Kozak, Christine A (2003) Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus. J Virol 77:5065-72
Denicourt, Catherine; Kozak, Christine A; Rassart, Eric (2003) Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing. J Virol 77:37-44
Carp, R I; Meeker, H C; Chung, R et al. (2002) Murine leukemia virus in organs of senescence-prone and -resistant mouse strains. Mech Ageing Dev 123:575-84

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