Multiple molecules exist on the surface of lymphocytes which are important for the development of the immune response. A major goal of these studies is to identify and structurally characterize these membrane-bound molecules, especially those present on cytotoxic T lymphocytes. Concordantly, it is important to have an understanding of the molecules encoded by infectious agents which are recognized by the immune system. Thus, the nature of the antigens in several viruses posing serious health problems is being investigated. Project areas include: (1) studies on the gene and protein structures of the human T cell receptor - T3 molecular complex, (2) characterization of the molecules of antigenic importance expressed by the AIDS virus, and (3) studies on antigenic variation in Herpes simplex virus type 1 (HSV-1) glycoproteins.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000352-04
Application #
3960566
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Fattakhova, Gul'nar; Masilamani, Madhan; Borrego, Francisco et al. (2006) The high-affinity immunoglobulin-E receptor (FcepsilonRI) is endocytosed by an AP-2/clathrin-independent, dynamin-dependent mechanism. Traffic 7:673-85
Maasho, Kerima; Masilamani, Madhan; Valas, Robert et al. (2005) The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation. Mol Immunol 42:1521-30
Maasho, Kerima; Opoku-Anane, Jessica; Marusina, Alina I et al. (2005) NKG2D is a costimulatory receptor for human naive CD8+ T cells. J Immunol 174:4480-4
Erman, Batu; Feigenbaum, Lionel; Coligan, John E et al. (2002) Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development. Nat Immunol 3:564-9
Zappacosta, F; Tabaczewski, P; Parker, K C et al. (2000) The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire. J Immunol 164:1906-15