The aim of this research proposal is to characterize monocyte/macrophage immune surveillance by defining the homeostatic trafficking signals used by these cells. Projects will include the isolation of hematopoietic progenitors and differentiation of these cells into myeloid cells to discern the phenotype and functional properties of various tissue specific macrophage populations. Other projects will include cloning and characterization of monocyte/macrophage specific genes involved in monocyte to macrophage/and or dendritic cell differentiation and cell trafficking. Projects: 1. In vitro differentiation of progenitors into monocytes -> macrophages/dendritic cells. 2. Ex vivo transfer of differentiated cells into recipient mice. 3. Characterization of monocyte/macrophage/dendritic cell specific genes or proteins. 4. Macrophage/dendritic cell apoptosis.
| Ge, Yun; Montano, Idalia; Rustici, Gabriella et al. (2006) Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood 108:4126-35 |
| Jackson, Sharon H; Yu, Cheng-Rong; Mahdi, Rashid M et al. (2004) Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling. J Immunol 172:2307-15 |
| Jackson, Sharon H; Devadas, Satish; Kwon, Jaeyul et al. (2004) T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 5:818-27 |
| Jackson, Sharon H; Alicea, Candido; Owens, Jennie W et al. (2002) Characterization of an early dendritic cell precursor derived from murine lineage-negative hematopoietic progenitor cells. Exp Hematol 30:430-9 |
| Jackson, S H; Miller, G F; Segal, B H et al. (2001) IFN-gamma is effective in reducing infections in the mouse model of chronic granulomatous disease (CGD). J Interferon Cytokine Res 21:567-73 |
