CD8 + T cells (TCD8+) play a crucial role in eradicating viral infections. Despite this, little attention has been paid to the ability of vaccines to induce TCD8+ memory. For viruses in which traditional vaccine approaches have not been successful, it is hoped that induction of TCD8+ memory will enhance immunity. To induce optimal TCD8+ responses to vaccines it is necessary to understand how primary TCD8+ cells are stimulated. The goal of this project is to answer the following questions; 1. Following a virus infection in what anatomical location are primary TCD8+ cells stimulated (local sites of infection, lymph nodes, spleen)? 2. What type of cell presents antigen to primary TCD8+ cells? 3. Is the antigen presenting cell infected, or does it present viral proteins obtained from infected cells? 4. How does these answers to questions 1-3 vary between different antigens encoded by the same virus and the same antigen encoded by different viruses?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000814-02
Application #
6099128
Study Section
Special Emphasis Panel (LVD)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
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