Etiology and Pathogenesis of Idiopathic Inflammatory Myopathy in Humans

Plotz, P H.

Abstract

ldiopathic inflammatory myopathy (poly/dermatomyositis) is an inflammatory disease of muscle in which characteristic autoantibodies occur. By applying a broad range of immunological, clinical, and epidemiological observations to a large (about 150) group of patients, we have developed evidence for subsets of patients which strongly suggest that the disease can be divided into more meaningful groups with different etiology and pathogenesis. So far, the groups of patients with anti-Jo-l antibodies and with antibodies to signal recognition peptide are clinically and epidemiologically as well as serologically distinct from each other and from other patients.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Intramural Research (Z01)
• Project #: 1Z01AR041074-02
• Application #: 3819298
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: Arthritis, Musculoskeletal, Skin Dis
• Country: United States

Publications

Plotz, Paul H (2014) Autoimmunity: the history of an idea. Arthritis Rheumatol 66:2915-20

Harris-Love, M O; Shrader, J A; Koziol, D et al. (2009) Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis. Rheumatology (Oxford) 48:134-9

Levine, Stuart M; Raben, Nina; Xie, Dan et al. (2007) Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis Rheum 56:2729-39

Nagaraju, Kanneboyina; Rider, Lisa G; Fan, Chenguang et al. (2006) Endothelial cell activation and neovascularization are prominent in dermatomyositis. J Autoimmune Dis 3:2

Howard, O M Zack; Dong, Hui Fang; Su, Shao Bo et al. (2005) Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Blood 105:4207-14

Oppenheim, Joost J; Dong, Hui Fang; Plotz, Paul et al. (2005) Autoantigens act as tissue-specific chemoattractants. J Leukoc Biol 77:854-61

Nagaraju, Kanneboyina; Casciola-Rosen, Livia; Lundberg, Ingrid et al. (2005) Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis Rheum 52:1824-35

Casciola-Rosen, Livia; Nagaraju, Kanneboyina; Plotz, Paul et al. (2005) Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 201:591-601

Plotz, Paul H (2003) The autoantibody repertoire: searching for order. Nat Rev Immunol 3:73-8

Howard, O M Zack; Dong, Hui Fang; Yang, De et al. (2002) Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med 196:781-91