Abstract

Affibody-AlexaFluor conjugates have been developed in and tested in vitro. In vivo studies await arrival of our new Xenogen imaging system. Methods for 18F labeling of Affibody molecules are being developed in collaboration with Dale Kiesewetter. Thermosensitive liposomes have been developed and characterized. Methodology for conjugation of these liposomes with targeting molecules (Affibody of scFv) is being developed in collaboration with Anu Puri and Robert Blumenthal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010727-01
Application #
7338810
Study Section
(ROB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Hassan, Moinuddin; Chernomordik, Victor; Zielinski, Rafal et al. (2012) In vivo method to monitor changes in HER2 expression using near-infrared fluorescence imaging. Mol Imaging 11:177-86
Kramer-Marek, Gabriela; Kiesewetter, Dale O; Martiniova, Lucia et al. (2008) [18F]FBEM-Z(HER2:342)-Affibody molecule-a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography. Eur J Nucl Med Mol Imaging 35:1008-18