We are analyzing the role of FGF and FGF receptors in stomach tumors using both DNA and antibody probes. Immuno-histochemistry of normal mouse gastrointestinal tissues shows localization of FGF receptor to the proximal small bowel and stomach. The ability of our antisera to react in immunohistochemistry will allow us to determine the usefulness of overexpression in diagnosis or prognosis of tumors with these amplifications. Future analysis may include immuno-histochemistry studies of primary human stomach, colon tumors or other tumor types that have receptor amplification.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BG006055-01
Application #
3804867
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Center Biologics Evaluation Research Transfusion
Department
Type
DUNS #
City
State
Country
United States
Zip Code