Abstract

Less than 1% of the total body magnesium is present in the peripheral blood. We developed an assay to determine the magnesium content of blood mononuclear cells as an index for intracellular magnesium and/or total body magnesium status. The blood magnesium status (plasma and red cell concentrations and mononuclear blood cell content of magnesium) was assessed in patients with parathyroid disease. The results show that patients with primary hyperparathyroidism have a decrease in the concentration of magnesium in red blood cells and in the content of magnesium in mononuclear blood cells compared with normal individuals. Patients with chronic hypoparathyroidism showed the opposite results. There was no significant change in plasma magnesium concentration among the groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010010-11
Application #
3963166
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lane, Jason W; Rehak, Nadja N; Hortin, Glen L et al. (2008) Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy. Clin Chim Acta 387:145-9
Haddad, Salim; Leitman, Susan F; Wesley, Robert A et al. (2005) Placebo-controlled study of intravenous magnesium supplementation during large-volume leukapheresis in healthy allogeneic donors. Transfusion 45:934-44
Bolan, Charles D; Yau, Yu Ying; Cullis, Herbert C et al. (2004) Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens. Transfusion 44:229-38
Bolan, Charles D; Wesley, Robert A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate administration in plateletpheresis: I. Associations with donor symptoms. Transfusion 43:1403-13
Bolan, Charles D; Cecco, Stacey A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. Metabolic effects. Transfusion 43:1414-22
Bolan, Charles D; Cecco, Stacey A; Wesley, Robert A et al. (2002) Controlled study of citrate effects and response to i.v. calcium administration during allogeneic peripheral blood progenitor cell donation. Transfusion 42:935-46
McKee, Mark D; Cecco, Stacey A; Niemela, Julie E et al. (2002) Effects of interleukin 2 therapy on lymphocyte magnesium levels. J Lab Clin Med 139:5-12
Bolan, C D; Greer, S E; Cecco, S A et al. (2001) Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion 41:1165-71