Abstract

Less than 1% of the total body magnesium is present in the peripheral blood. We developed an assay to determine the magnesium content and concentration of blood mononuclear cells as an index for intracellular magnesium and/or total body magnesium status. We determined plasma, red blood cell and mononuclear blood cell magnesium concentrations in normal individuals between the ages of twenty and seventy. We determined these same magnesium parameters in women with the premenstrual syndrome and the control group at four points during the menstrual cycle. The results show magnesium parameters do not differ with age. The magnesium concentration of red blood cells decreases significantly during the menstrual cycle in women with the premenstrual syndrome.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010010-14
Application #
3916509
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lane, Jason W; Rehak, Nadja N; Hortin, Glen L et al. (2008) Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy. Clin Chim Acta 387:145-9
Haddad, Salim; Leitman, Susan F; Wesley, Robert A et al. (2005) Placebo-controlled study of intravenous magnesium supplementation during large-volume leukapheresis in healthy allogeneic donors. Transfusion 45:934-44
Bolan, Charles D; Yau, Yu Ying; Cullis, Herbert C et al. (2004) Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens. Transfusion 44:229-38
Bolan, Charles D; Wesley, Robert A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate administration in plateletpheresis: I. Associations with donor symptoms. Transfusion 43:1403-13
Bolan, Charles D; Cecco, Stacey A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. Metabolic effects. Transfusion 43:1414-22
McKee, Mark D; Cecco, Stacey A; Niemela, Julie E et al. (2002) Effects of interleukin 2 therapy on lymphocyte magnesium levels. J Lab Clin Med 139:5-12
Bolan, Charles D; Cecco, Stacey A; Wesley, Robert A et al. (2002) Controlled study of citrate effects and response to i.v. calcium administration during allogeneic peripheral blood progenitor cell donation. Transfusion 42:935-46
Bolan, C D; Greer, S E; Cecco, S A et al. (2001) Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion 41:1165-71