This project investigates the degradation of factor VIII procoagulant (VIII:C) and factor VIII:C coagulant antigens (VIII:C Ag) by serine proteases and characterizes the degradation products in terms of size, using both procoagulant assays and radioimmunoassays. The nonfunctional hemophilic VIII:C from cross-reacting material positive (CRM+) hemophiliacs will be similarly studied to see if any differences from normal can be found.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010069-05
Application #
4692035
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code