Neuropsychiatric Evaluation of Drug Using HIV Positive/Negative Individuals

Cadet, J L.

Abstract

The purpose of this project is to continue assess the neuropsychiatric status of HIV-positive individuals who have abused drugs over a long period of their lives. This protocol includes 60 HIV positive participants who do not show any overt signs or symptoms related to AIDS. Data collected from the HIV positive individuals are being compared to seronegative individuals with similar drug history. Preliminary analyses suggest that HIV-positive individuals have greater asymmetry than HIV-negative subjects on EEG and blood flow. The blood flow data are the first such demonstration while the EEG data replicate those of others.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Drug Abuse (NIDA)
• Type: Intramural Research (Z01)
• Project #: 1Z01DA000174-03
• Application #: 6161708
• Study Section: Special Emphasis Panel (NS)
• Support Year: 3
• Fiscal Year: 1997

Institution

• Name: National Institute on Drug Abuse
• Country: United States

Publications

Atianjoh, Fidelis E; Ladenheim, Bruce; Krasnova, Irina N et al. (2008) Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb. Eur J Pharmacol 589:94-7

Deng, Xiaolin; Ladenheim, Bruce; Jayanthi, Subramaniam et al. (2007) Methamphetamine administration causes death of dopaminergic neurons in the mouse olfactory bulb. Biol Psychiatry 61:1235-43

Sokolov, Boris P; Cadet, Jean L (2006) Methamphetamine causes alterations in the MAP kinase-related pathways in the brains of mice that display increased aggressiveness. Neuropsychopharmacology 31:956-66

Cai, Ning Sheng; McCoy, Michael T; Ladenheim, Bruce et al. (2006) Serial analysis of gene expression in the rat striatum following methamphetamine administration. Ann N Y Acad Sci 1074:13-30

Krasnova, Irina N; Ladenheim, Bruce; Cadet, Jean Lud (2005) Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway. FASEB J 19:851-3

Jayanthi, Subramaniam; Deng, Xiaolin; Noailles, Pierre-Antoine H et al. (2004) Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades. FASEB J 18:238-51

Sokolov, Boris P; Schindler, Charles W; Cadet, Jean Lud (2004) Chronic methamphetamine increases fighting in mice. Pharmacol Biochem Behav 77:319-26

Yu, Jing; Wang, Jing; Cadet, Jean Lud et al. (2004) Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brain. Brain Res 1007:124-31

Lyles, Johnalyn; Cadet, Jean Lud (2003) Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Brain Res Rev 42:155-68

Cadet, Jean Lud; Jayanthi, Subramaniam; Deng, Xiaolin (2003) Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis. FASEB J 17:1775-88