Several clinical studies are performed to determine objective and subjective measures associated with smoking and tobacco withdrawal. The results of these studies are applied to develop paradigms for testing of drugs for the treatment of nicotine withdrawal. Neurophysiologic data indicate that nicotine acts on neural substrates involved in attention, cognition and memory. For example, the effects of mecamylamine, a centrally acting nicotinic antagonist is studied to determine the contribution of tonic cholinergic mechanisms on the EEG and cognitive tasks in smokers and nonsmokers. The ability of transcranially delivered electrostimulation to alleviate nicotine withdrawal was evaluated in a treatment protocol. The efficacy of transdermally delivered nicotine to diminish signs and symptoms of tobacco spontaneous withdrawal are tested in a residential study. The effects of nicotine withdrawal on delayed auditory feedback - a proposed measure of attention and distraction - is being evaluated. The interaction of caffeine and nicotine after overnight abstinence was assessed. Dependent measures for these studies include: Gordon vigilance task (with and without distracters), word memory, PAB (performance) spontaneous EEG, evoked potentials, blood pressure, heart rate (physiologic); withdrawal scales, craving, drug liking, drug identification (subjective). Studies on the effects of smokeless tobacco products, and a newly developed denicotinized cigarette are completed. In an ongoing project, the effects of cigarettes that deliver nicotine from placebo cigarettes were tested in a spaced-smoking paradigm. In another study, the effects of the denicotinized cigarettes in a rapid smoking procedure are evaluated. Genetic mechanisms involved in the effect and appeal of cigarette smoking and tobacco withdrawal are investigated. These studies contribute to an understanding of the mechanisms of nicotine addiction and are also of practical value in the development of more effective medications for treating nicotine dependence and withdrawal.
| van den Bree, Marianne B M; Whitmer, Michelle D; Pickworth, Wallace B (2004) Predictors of smoking development in a population-based sample of adolescents: a prospective study. J Adolesc Health 35:172-81 |
| Aung, A Thiri; Pickworth, Wallace B; Moolchan, Eric T (2004) History of marijuana use and tobacco smoking topography in tobacco-dependent adolescents. Addict Behav 29:699-706 |
| Lee, Eun M; Malson, Jennifer L; Moolchan, Eric T et al. (2004) Quantitative comparisons between a nicotine delivery device (Eclipse) and conventional cigarette smoking. Nicotine Tob Res 6:95-102 |
| Pickworth, Wallace B; Lee, Eun M; Abreu, Mary E et al. (2004) A laboratory study of hydromorphone and cyclazocine on smoking behavior in residential polydrug users. Pharmacol Biochem Behav 77:711-5 |
| Ayo-Yusuf, O A; Swart, T J P; Pickworth, W B (2004) Nicotine delivery capabilities of smokeless tobacco products and implications for control of tobacco dependence in South Africa. Tob Control 13:186-9 |
| Haverkos, Harry W; Soon, Guoxing; Steckley, Stacey L et al. (2003) Cigarette smoking and cervical cancer: Part I: a meta-analysis. Biomed Pharmacother 57:67-77 |
| Pickworth, Wallace B; O'Hare, Elizabeth D; Fant, Reginald V et al. (2003) EEG effects of conventional and denicotinized cigarettes in a spaced smoking paradigm. Brain Cogn 53:75-81 |
| Lee, Eun M; Malson, Jennifer L; Waters, Andrew J et al. (2003) Smoking topography: reliability and validity in dependent smokers. Nicotine Tob Res 5:673-9 |
| Dallery, Jesse; Houtsmuller, Elisabeth J; Pickworth, Wallace B et al. (2003) Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking. Psychopharmacology (Berl) 165:172-80 |
| Malson, Jennifer L; Lee, Eun M; Murty, Ram et al. (2003) Clove cigarette smoking: biochemical, physiological, and subjective effects. Pharmacol Biochem Behav 74:739-45 |
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