Substantial progress has been made in examining the mechanism of action and the effects of amphetamine as well as amphetamine analogs. We have found that 3H-amphetamine is sequestered by synaptosomal fractions from brain. The neurotoxic effects of MDMA on brain serotonin neurons has been explored further by both biochemical techniques as well as autoradiographical techniques. Overall, these studies elucidate the mechanism of action of amphetamine as well as further explain the neurotoxic effects of drugs like MDMA.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000302-03
Application #
3853741
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code