The aim of this project is to investigate the molecular mechanisms involved in signal reception and transduction of the chemical senses, taste and smell. Major goals are characterization of the receptors involved, their distribution and specificity. Studies will also characterize the coupling of these receptors to production of secondary messengers, including the proteins with which the receptors interact and the mechanisms of desensitization and adaptation of the signal pathways.
| Nguyen, Minh Q; Zhou, Zhishang; Marks, Carolyn A et al. (2007) Prominent roles for odorant receptor coding sequences in allelic exclusion. Cell 131:1009-17 |
| Huang, Angela L; Chen, Xiaoke; Hoon, Mark A et al. (2006) The cells and logic for mammalian sour taste detection. Nature 442:934-8 |
| Chandrashekar, Jayaram; Hoon, Mark A; Ryba, Nicholas J P et al. (2006) The receptors and cells for mammalian taste. Nature 444:288-94 |
| Mueller, Ken L; Hoon, Mark A; Erlenbach, Isolde et al. (2005) The receptors and coding logic for bitter taste. Nature 434:225-9 |
| Zhang, Yifeng; Hoon, Mark A; Chandrashekar, Jayaram et al. (2003) Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112:293-301 |
| Zhao, Grace Q; Zhang, Yifeng; Hoon, Mark A et al. (2003) The receptors for mammalian sweet and umami taste. Cell 115:255-66 |
| Nelson, Greg; Chandrashekar, Jayaram; Hoon, Mark A et al. (2002) An amino-acid taste receptor. Nature 416:199-202 |
| Martini, S; Silvotti, L; Shirazi, A et al. (2001) Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ. J Neurosci 21:843-8 |
| Nelson, G; Hoon, M A; Chandrashekar, J et al. (2001) Mammalian sweet taste receptors. Cell 106:381-90 |
| Chandrashekar, J; Mueller, K L; Hoon, M A et al. (2000) T2Rs function as bitter taste receptors. Cell 100:703-11 |
Showing the most recent 10 out of 13 publications
