These studies involve the identification of receptors for gastrointestinal peptides by developing selective radioligands for specific receptors, specific potent antagonists, and the characterization of receptors using these ligands, antagonists, cross-linking studies, solubilization and eventually structural determination.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
City
State
Country
United States
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Nuche-Berenguer, Bernardo; Jensen, R T (2015) Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms. Biochim Biophys Acta 1853:2371-82
Alves, Bryce N; Marshall, Kristen; Tamang, David L et al. (2009) Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct 27:296-308
Berna, Marc J; Tapia, Jose A; Sancho, Veronica et al. (2009) Gastrointestinal growth factors and hormones have divergent effects on Akt activation. Cell Signal 21:622-38
Alves, Bryce N; Leong, Jeff; Tamang, David L et al. (2009) Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol 86:701-12
Gonzalez, Nieves; Nakagawa, Tomoo; Mantey, Samuel A et al. (2009) Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. J Pharmacol Exp Ther 331:265-76
Seidita, G; Mirisola, M; D'Anna, R P et al. (2008) Analysis of the gastrin-releasing peptide receptor gene in Italian patients with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 147B:807-13
Igarashi, Hisato; Ito, Tetsuhide; Kuwano-Kojima, Mizuho et al. (2008) Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats. Pancreas 37:236-8
Moody, Terry W; Pradhan, Tapas; Mantey, Samuel A et al. (2008) Bombesin marine toxin conjugates inhibit the growth of lung cancer cells. Life Sci 82:855-61
Schumann, Michael; Nakagawa, Tomoo; Mantey, Samuel A et al. (2008) Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor). Biochem Pharmacol 75:1170-85
Jensen, R T; Battey, J F; Spindel, E R et al. (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60:1-42

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