Abstract

This project includes studies investigating the relationship for various gastrointestinal peptides between receptor occupation to subsequent changes induced in cellular processes, the characterization of the various second messengers including cyclic nucleotides, changes in cellular calcium, breakdown of phosphoinositides, generation of diacylglycerol as well as characterization of more distal steps in cell activation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK053101-02
Application #
3876434
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

González, Nieves; Mantey, Samuel A; Pradhan, Tapas K et al. (2009) Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides 30:1473-86
Gonzalez, Nieves; Nakagawa, Tomoo; Mantey, Samuel A et al. (2009) Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. J Pharmacol Exp Ther 331:265-76
Gonzalez, Nieves; Moody, Terry W; Igarashi, Hisato et al. (2008) Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr Opin Endocrinol Diabetes Obes 15:58-64
Jensen, R T; Battey, J F; Spindel, E R et al. (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60:1-42
Gonzalez, Nieves; Hocart, Simon J; Portal-Nunez, Sergio et al. (2008) Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor. J Pharmacol Exp Ther 324:463-74
Berna, Marc J; Jensen, Robert T (2007) Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases. Curr Top Med Chem 7:1211-31
Moody, Terry W; Mantey, Samuel A; Fuselier, Joseph A et al. (2007) Vasoactive intestinal peptide-camptothecin conjugates inhibit the proliferation of breast cancer cells. Peptides 28:1883-90
Berna, Marc J; Tapia, Jose A; Sancho, Veronica et al. (2007) Progress in developing cholecystokinin (CCK)/gastrin receptor ligands that have therapeutic potential. Curr Opin Pharmacol 7:583-92
Berna, Marc J; Hoffmann, K Martin; Tapia, Jose A et al. (2007) CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta 1773:483-501
Corleto, V D; Severi, C; Romano, G et al. (2006) Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells. Neurogastroenterol Motil 18:217-25

Showing the most recent 10 out of 27 publications