Diabetes Mellitus/Chronic Diseases In Gila River Indians

Knowler, William C.

Abstract

The purpose of this project is to identify the determinants of type 2 diabetes, obesity, and other chronic diseases in the Pima Indians, and elucidate their natural history. Genetic and environmental risk factors for type 2 diabetes have been studied. The residents of the study area, approximately 8000 people, have participated in a longitudinal population study since 1965, allowing observations of the natural history of diabetes mellitus. Risk factors for obesity, hypertension, and nephropathy are also studied, along with the relationships of these diseases to diabetes and their effects on mortality rates. The genetics of diabetes is studied by means of family studies and relationships of genetic markers to disease. The roles of obesity, serum insulin concentrations, impaired glucose regulation, occupational and leisure-time physical activity and diabetes in relatives are assessed. Studies of the genetics of type 2 diabetes and obesity are described in project report # Z01 DK 69028 PECR. Behavioral risk factors contribute to the incidence of type 2 diabetes in this population, as self-reported physical inactivity predicts diabetes. There was no relationship, however, with self-reported alcohol consumption.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK069000-40
• Application #: 7153435
• Study Section: (PECR)
• Support Year: 40
• Fiscal Year: 2005

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney
• Country: United States

Publications

Perreault, Leigh; Kahn, Steven E; Christophi, Costas A et al. (2009) Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program. Diabetes Care 32:1583-8

International Expert Committee (2009) International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 32:1327-34

Moore, Allan F; Jablonski, Kathleen A; McAteer, Jarred B et al. (2008) Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes 57:2503-10

Crandall, Jill P; Knowler, William C; Kahn, Steven E et al. (2008) The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab 4:382-93

Rubin, Richard R; Ma, Yong; Marrero, David G et al. (2008) Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care 31:420-6

Sahota, Puneet K C; Knowler, William C; Looker, Helen C (2008) Depression, diabetes, and glycemic control in an American Indian community. J Clin Psychiatry 69:800-9

Florez, J C; Jablonski, K A; McAteer, J et al. (2008) Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51:451-7

Mason, Clinton C; Hanson, Robert L; Knowler, William C (2007) Progression to type 2 diabetes characterized by moderate then rapid glucose increases. Diabetes 56:2054-61

Pavkov, Meda E; Hanson, Robert L; Knowler, William C et al. (2007) Changing patterns of type 2 diabetes incidence among Pima Indians. Diabetes Care 30:1758-63

Lachin, John M; Christophi, Costas A; Edelstein, Sharon L et al. (2007) Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program. Diabetes 56:1153-9