Abstract

The purpose if the project is to determine the relationship of maternal diabetes and other early developmental factors to later risk of metabolic disease. The risk of early onset obesity and type 2 diabetes is greatly increased in offspring exposed to maternal diabetes in utero. Insulin secretion was found to be lower in normal glucose tolerant offspring of people with early onset type 2 diabetes. This impairment may be worsened by exposure to a diabetic environment in utero. Continuing recruitment of young Pima Indians in the longitudinal study will help elucidate effects of maternal diabetes, birth weight, and early growth on risks of obesity and diabetes in adolescents and young adults.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK069001-35
Application #
6984155
Study Section
(PECR)
Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
2004
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Franks, Paul W; Looker, Helen C; Kobes, Sayuko et al. (2006) Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes 55:460-5
Touger, Leslie; Looker, Helen C; Krakoff, Jonathan et al. (2005) Early growth in offspring of diabetic mothers. Diabetes Care 28:585-9
Stefan, Norbert; Weyer, Christian; Levy-Marchal, Claire et al. (2004) Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight. Metabolism 53:904-11
Gautier, J F; Wilson, C; Weyer, C et al. (2001) Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes 50:1828-33
Lindsay, R S; Dabelea, D; Roumain, J et al. (2000) Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes 49:445-9
Dabelea, D; Knowler, W C; Pettitt, D J (2000) Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians. J Matern Fetal Med 9:83-8
Dabelea, D; Hanson, R L; Lindsay, R S et al. (2000) Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 49:2208-11
Lindsay, R S; Hanson, R L; Bennett, P H et al. (2000) Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothers. Diabetes Care 23:1249-54