The study relates outcomes and causes of death to events or risk factors measured in life among Pima Indian residents of the Gila River Indian Community, particularly in relation to diabetes and its complications, cardiovascular diseases and gallbladder disease. Causes of death and postmortem characteristics of Pima Indians of the Gila River Indian Community are investigated. Death certificates are obtained on all members of the Gila River Indian Community who have taken part in the ongoing longitudinal studies of diabetes and its complications. Postmortem examination results and all available medical records pertaining to the dececdents are reviewed to ascertain conditions present at the time of death and ascertain the underlying and contributory causes of death as precisely as possible. The records are reviewed in a standardized way for evidence of the complications of diabetes, vascular disease, neoplasia and other conditions. The data are used to determine the causes of death and incidence of complications associated with diabetes and other characteristics identified during life by the longitudinal epidemiologic studies in the population. Detailed review of causes of death from 1965-1999 has been completed and those from 2000 to the present time are ongoing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK069006-32
Application #
6673880
Study Section
(PECR)
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
2002
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Looker, Helen C; Fagot-Campagna, Anne; Gunter, Elaine W et al. (2007) Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res Rev 23:193-201
Jimenez-Corona, Aida; Nelson, Robert G; Sievers, Maurice L et al. (2006) Electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetes. Am Heart J 151:1080-6
Hoehner, Christine M; Williams, Desmond E; Sievers, Maurice L et al. (2006) Trends in heart disease death rates in diabetic and nondiabetic Pima Indians. J Diabetes Complications 20:8-13
Pavkov, Meda E; Bennett, Peter H; Sievers, Maurice L et al. (2005) Predominant effect of kidney disease on mortality in Pima Indians with or without type 2 diabetes. Kidney Int 68:1267-74
Saremi, Aramesh; Nelson, Robert G; Tulloch-Reid, Marshall et al. (2005) Periodontal disease and mortality in type 2 diabetes. Diabetes Care 28:27-32
Pavkov, Meda E; Sievers, Maurice L; Knowler, William C et al. (2004) An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapy. Diabetes Care 27:1132-6
Howard, Barbara V; Rodriguez, Beatriz L; Bennett, Peter H et al. (2002) Prevention Conference VI: Diabetes and Cardiovascular disease: Writing Group I: epidemiology. Circulation 105:e132-7
Jacobsson, L T; Turesson, C; Hanson, R L et al. (2001) Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima Indians. Arthritis Rheum 44:1170-6
Sievers, M L; Bennett, P H; Roumain, J et al. (1999) Effect of hypertension on mortality in Pima Indians. Circulation 100:33-40
Sievers, M L; Bennett, P H; Nelson, R G (1999) Effect of glycemia on mortality in Pima Indians with type 2 diabetes. Diabetes 48:896-902