Abstract

Four compounds either being tested or being considered for testing by the NTP were investigated. Two major urinary metabolites of 1,2-dihydro-2,2,4-trimethylquinoline were identified as the 0-sulfate conjugte of 1,2-dihydro-6-hydroxy-2,2,4-trimethylquinoline. The chemical disposition and to some extent the covalent binding of l-chloro-2-methylpropene and 3-chloro-2-methylpropene were investigated. The most noteworthy observation in these studies is that about 33% of the dose of 1-chloro-2-methyl propene is exhaled, unmetabolized, in the first 6 hr. The major urinary metabolite of 3-chloro-2-methylpropene was found to be N-agetyl-S-(2-methylprop-2-enyl)-L-cysteine. It was demonstrated that the naturally-occurring flavone, kaempferol, was hydroxylated to give quercetin in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021075-02
Application #
4693191
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lo, Yi-Ching; Liu, Yuxin; Lin, Yi-Chin et al. (2008) Neuronal effects of 4-t-Butylcatechol: a model for catechol-containing antioxidants. Toxicol Appl Pharmacol 228:247-55
Clayton, Natasha P; Yoshizawa, Katsuhiko; Kissling, Grace E et al. (2007) Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Exp Toxicol Pathol 58:223-36
Ferguson, Ling-Jen Chen; Lebetkin, Edward H; Lih, Fred B et al. (2007) 14C-labeled pulegone and metabolites binding to alpha2u-globulin in kidneys of male F-344 rats. J Toxicol Environ Health A 70:1416-23
Garner, C E; Sumner, S C J; Davis, J G et al. (2006) Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration. Toxicol Appl Pharmacol 215:23-36
Chen, Ling-Jen; DeRose, Eugene F; Burka, Leo T (2006) Metabolism of furans in vitro: ipomeanine and 4-ipomeanol. Chem Res Toxicol 19:1320-9
Sanders, J M; Chen, L-J; Lebetkin, E H et al. (2006) Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica 36:103-17
Chen, L-J; Lebetkin, E H; Sanders, J M et al. (2006) Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice. Xenobiotica 36:515-34
Sanders, J M; Lebetkin, E H; Chen, L-J et al. (2006) Disposition of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents. Xenobiotica 36:824-37
Mathews, James M; Etheridge, Amy S; Valentine, John L et al. (2005) Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro. Drug Metab Dispos 33:1555-63
Irwin, Richard D; Parker, Joel S; Lobenhofer, Edward K et al. (2005) Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen. Toxicol Pathol 33:111-7

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