Abstract

The major goals of these studies are to elucidate the individual roles of COX-1 and COX-2 in normal physiology and in various pathological states using the COX deficient mice. Included in these studies are the roles of the COX isoforms in gastric ulceration, lung inflammation, vascular development and blood pressure regulation. Additionally, effort within the laboratory has focused on using COX-1 and COX-2 deficient mouse ES cells to study the roles of COX-1 and COX-2 in endothelial cell development and angiogenesis. Studies suggest that neither the deficiency of COX-1 or COX-2 inhibited mouse ES cell differentiation into endothelial-like cells in vitro. Whereas studies with COX-1 and COX-2 selective inhibitors have indicated that the COX-2 inhibitors inhibits endothelial-like cell development by a COX independent mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021179-14
Application #
7327248
Study Section
(LECM)
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Aid, Saba; Langenbach, Robert; Bosetti, Francesca (2008) Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation 5:17
Choi, Sang-Ho; Langenbach, Robert; Bosetti, Francesca (2008) Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J 22:1491-501
Narasimha, Ajay; Watanabe, Junji; Lin, James A et al. (2007) A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors. Prostaglandins Other Lipid Mediat 84:24-33
Gitlin, Jonathan M; Trivedi, Darshini B; Langenbach, Robert et al. (2007) Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice. Cardiovasc Res 73:227-36
Carey, Michelle A; Bradbury, J Alyce; Seubert, John M et al. (2005) Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J Immunol 175:6878-84
Rao, Jagadeesh S; Langenbach, Robert; Bosetti, Francesca (2005) Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse. Brain Res Mol Brain Res 139:217-24
Kawada, Noritaka; Solis, Glenn; Ivey, Nathan et al. (2005) Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction. Hypertension 45:1131-8
Wang, Tongguang; Pei, Zhong; Zhang, Wei et al. (2005) MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J 19:1134-6
Steiner, Alexandre A; Rudaya, Alla Y; Robbins, Jared R et al. (2005) Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses. Am J Physiol Regul Integr Comp Physiol 289:R1253-7
Salvatore, Michael F; Fisher, Brent; Surgener, Stewart P et al. (2005) Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain Res Mol Brain Res 139:341-7

Showing the most recent 10 out of 19 publications