of Work: This project seeks to develop new statistical techniques for problems in human development and to apply existing techniques to those problems in novel ways. Work continues in four areas: (1) statistical modeling of the birth weight distribution in human populations, (2) regression modeling of developmental trajectories of reproductive hormones in children through puberty, (3) regression modeling of the effects of soy diet on cholesterol and sex hormone binding globulin, (4) developing methods to test whether log link or the logit link is better suited to a given data set. Development of a satisfactory model for birthweight distributions will facilitate a refined understanding of the relationship of birthweight to infant mortality. We are applying a model that we developed to U.S. birthweight and perinatal mortality records to assess how well mortality rates are predicted by distributional features measured by our technique. Having found that certain nonlinear regression models can parsimoniously describe changes in mean hormone levels through puberty, we are now examining what similar models can tell us about changes through puberty in the degree of regularity (assessed using entropy measures) exhibited in a series of 49 consecutive serum hormone measurements over 8 hr. The degree of regularity should increase as children mature.
| Rowland, Andrew S; Skipper, Betty; Rabiner, David L et al. (2008) The shifting subtypes of ADHD: classification depends on how symptom reports are combined. J Abnorm Child Psychol 36:731-43 |
| Kamel, Freya; Umbach, David M; Stallone, Lillian et al. (2008) Association of lead exposure with survival in amyotrophic lateral sclerosis. Environ Health Perspect 116:943-7 |
| Rowland, Andrew S; Umbach, David M; Bohlig, E Michael et al. (2007) Modifying the response labels of an ADHD teacher rating scale: psychometric and epidemiologic implications. J Atten Disord 11:384-97 |
| Kamel, F; Tanner, Cm; Umbach, Dm et al. (2007) Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165:364-74 |
| Chen, Honglei; Richard, Marie; Sandler, Dale P et al. (2007) Head injury and amyotrophic lateral sclerosis. Am J Epidemiol 166:810-6 |
| Rozman, Karl K; Bhatia, Jatinder; Calafat, Antonia M et al. (2006) NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula. Birth Defects Res B Dev Reprod Toxicol 77:280-397 |
| Rozman, Karl K; Bhatia, Jatinder; Calafat, Antonia M et al. (2006) NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein. Birth Defects Res B Dev Reprod Toxicol 77:485-638 |
| Terry, Paul D; Kamel, Freya; Umbach, David M et al. (2004) VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS). J Neurogenet 18:429-34 |
| Kamel, Freya; Umbach, David M; Lehman, Teresa A et al. (2003) Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ Health Perspect 111:1335-9 |
| Rowland, Andrew S; Umbach, David M; Stallone, Lil et al. (2002) Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North Carolina. Am J Public Health 92:231-4 |
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