of Work: This research tests the hypothesis that commonly inherited allelic variants of certain genes, in conjunction with environmental exposures, affect a persons risk of developing disease. The primary focus of this work has been on bladder cancer and prostate cancers, with new studies in lung cancer and meningioma. Although the primary focus of past research has been on polymorphisms in receptors and carcinogen metabolism genes, we are increasingly focusing our efforts on polymorphisms in DNA repair genes and on the development of functional assays for DNA repair that can be applied in population- based samples. We have recently published the results of a second study on the VDR receptor polymorphism and prostate cancer risk, and in collaboration with the Bell laboratory on two genes involved in androgen metabolism, CYP17 and SRD5A2, in relation to prostate cancer risk. In collaboration with Ms. Devereux we have submitted for publication a manuscript describing a search for new polymorphisms in the p16 gene and the results of a case-control comparison for selected polymorphisms and bladder cancer risk. a new study described in Exposure-specific mutation in critical target genes also contain central components relating to genetic susceptibility. The study Fluorescence bronchoscopy and molecular characterization of abnormal bronchial lesions: novel approaches for early detection of lung cancer in high-risk patients obtains normal blood for genotyping of selected DNA repair genes in cancer cases and controls and includes the collection of normal bronchial epithelium for in vitro measurement of DNA repair capability in target tissue. - genetic susceptibility, molecular epidemiology,bladder cancer, polymorphism, prostate cancer, lung cancer - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES049033-03
Application #
6289997
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Wilson, L E; Harlid, S; Xu, Z et al. (2017) An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort. Int J Obes (Lond) 41:194-199
Xu, Zongli; Langie, Sabine A S; De Boever, Patrick et al. (2017) RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip. BMC Genomics 18:4
Xu, Zongli; Taylor, Jack A; Leung, Yuet-Kin et al. (2016) oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics 32:3667-3669
Wilson, Lauren E; D'Aloisio, Aimee A; Sandler, Dale P et al. (2016) Long-term use of calcium channel blocking drugs and breast cancer risk in a prospective cohort of US and Puerto Rican women. Breast Cancer Res 18:61
Niu, Liang; Xu, Zongli; Taylor, Jack A (2016) RCP: a novel probe design bias correction method for Illumina Methylation BeadChip. Bioinformatics 32:2659-63
Xu, Zongli; Niu, Liang; Li, Leping et al. (2016) ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip. Nucleic Acids Res 44:e20
Wilson, Lauren E; Kim, Sangmi; Xu, Zongli et al. (2015) Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. PLoS One 10:e0138920
Bensen, Jeannette T; Xu, Zongli; McKeigue, Paul M et al. (2014) Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate 74:1-9
Harlid, Sophia; Xu, Zongli; Panduri, Vijayalakshmi et al. (2014) CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. Environ Health Perspect 122:673-8

Showing the most recent 10 out of 40 publications