Abstract

Quantitative Mass Spectrometry incorporates collaborative projects in which the Mass Spectrometry Group provides quantitative information about, typically, small molecules by GC/MS, LC/MS and LC/MS/MS or a combination. An example of the types of projects this includes is the isoprostane analyses undertaken as part of the NIEHS led study of biomarkers of oxidative stress. We currently have three major collaborations underway: 1) with Darryl Zeldin on Atherosclerosis Risk In Communities (ARIC) Ancillary Study; 2) with James Mohler on Interference with the Androgen Receptor and its Ligands in Recurrent Prostate Cancer; and 3) with Ron Cannon on fatty acid profile differences in a mutant mouse strain compared to wild type.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES050167-09
Application #
7328423
Study Section
(LSB)
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cheng, Jennifer; Dackor, Ryan T; Bradbury, J Alyce et al. (2016) Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis. FASEB J 30:160-73
Cheng, Jennifer; Edin, Matthew L; Hoopes, Samantha L et al. (2014) Vascular characterization of mice with endothelial expression of cytochrome P450 4F2. FASEB J 28:2915-31
Takeda, Yukimasa; Kang, Hong Soon; Lih, Fred B et al. (2014) Retinoid acid-related orphan receptor ?, ROR?, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucleic Acids Res 42:10448-59
Zha, Weibin; Edin, Matthew L; Vendrov, Kimberly C et al. (2014) Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity. J Lipid Res 55:2124-36
Schuck, Robert N; Zha, Weibin; Edin, Matthew L et al. (2014) The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease. PLoS One 9:e110162
Theken, Katherine N; Schuck, Robert N; Edin, Matthew L et al. (2012) Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. Atherosclerosis 222:530-6
Panigrahy, Dipak; Edin, Matthew L; Lee, Craig R et al. (2012) Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest 122:178-91
Panigrahy, Dipak; Greene, Emily R; Pozzi, Ambra et al. (2011) EET signaling in cancer. Cancer Metastasis Rev 30:525-40
Deng, Yangmei; Edin, Matthew L; Theken, Katherine N et al. (2011) Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J 25:703-13
Lee, Craig R; Imig, John D; Edin, Matthew L et al. (2010) Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J 24:3770-81

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