This year, working in close collaboration with collaborators, we had three major accomplishments in the mismatch repair field. (1) We completed experiments indicating that exonuclease 1, which participates in the excision step of MMR, is also important for cellular responses to DNA damage induced by environmental agents. (2) We finished experiments demonstrating that Saccharomyces cereivisiae MutL alpha is a mismatch repair endonuclease. (3) We directly visualized asymmetric adenine nucleotide induced conformational changes in MutL alpha, leading to a better understanding of the role of this heterodimer in mismatch repair.
| Burgers, Peter M J; Kunkel, Thomas A (2017) Eukaryotic DNA Replication Fork. Annu Rev Biochem 86:417-438 |
| Kunkel, Thomas A; Erie, Dorothy A (2015) Eukaryotic Mismatch Repair in Relation to DNA Replication. Annu Rev Genet 49:291-313 |
| St Charles, Jordan A; Liberti, Sascha E; Williams, Jessica S et al. (2015) Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae. DNA Repair (Amst) 31:41-51 |
| Liu, Songbai; Lu, Guojun; Ali, Shafat et al. (2015) Okazaki fragment maturation involves ?-segment error editing by the mammalian FEN1/MutS? functional complex. EMBO J 34:1829-43 |
| Makarova, Alena V; Nick McElhinny, Stephanie A; Watts, Brian E et al. (2014) Ribonucleotide incorporation by yeast DNA polymerase ?. DNA Repair (Amst) 18:63-7 |
| Schaetzlein, Sonja; Chahwan, Richard; Avdievich, Elena et al. (2013) Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A 110:E2470-9 |
| Sparks, Justin L; Chon, Hyongi; Cerritelli, Susana M et al. (2012) RNase H2-initiated ribonucleotide excision repair. Mol Cell 47:980-6 |
| Lujan, Scott A; Williams, Jessica S; Pursell, Zachary F et al. (2012) Mismatch repair balances leading and lagging strand DNA replication fidelity. PLoS Genet 8:e1003016 |
| Kunkel, Thomas A (2011) Balancing eukaryotic replication asymmetry with replication fidelity. Curr Opin Chem Biol 15:620-6 |
| Jirawatnotai, Siwanon; Hu, Yiduo; Michowski, Wojciech et al. (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474:230-4 |
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