Abstract

In meeting the goals and objectives of FMIC, the center continues to:? ? -Service and maintain state-of-the-art equipment for unlimited access by intramural scientists.? -Provide investigator training in the use and analysis of fluorescence and optical-based techniques.? -Develop and optimize experimental protocols in collaboration with intramural scientists.? -Maintain and develop state-of-the-art analysis tools and protocols in collaboration with investigators? -Monitor and incorporate emerging fluorescence and optical technologies that will support the mission of NIEHS into FMIC.? ? During this fiscal year, FMIC has collaborated and supported 40 Principle Investigators from all 5 programs within the NIEHS DIR.? ? Some publications from this FY resulting from work in the center:? ? Yang S et al, 2008 International Neurochem. Res; epub? Yang, L. et al, 2008 J. Biol. Chem. 283:11823-11831? Yan, J. et al, 2008 Cancer Research 68:4269-4276? Wang X et al, 2008 Toxicology and Applied Pharmacology 230:167-74n? Smyth, J.T. et al, 2008 J. Cell Sci. 121:762-772? Mitchell, J. et al, 2008 Current Biology, epub? Li Y et al, 2008, epub? Kim, Y-S. et al, 2008 Mol. Cell Biol. 28:2358-2369? Junguo Zhou et al, 2008 Molecular Endocrinology 22:1521-1534? Hu, X. et al, 2008 J. Immunology, epub? He Y-Y et al, 2008 Photochem Photobiol 84:69-74? He Y-Y et al, 2008 Cancer Research 68:3752-3758? Hartz AMS et al, 2008 FASEB J 22:2723-33? Gao X et al, 2008 Environ Health Perspect 116:193-8? DeHaven, W.I. et al, 2008 J. Biol. Chem.283:19265-19273? Brynczka, C. and Merrick, B.A. 2008 Differentiation 76:795-808? Bow, D.A. et al, 2008 Drug Metab Dispos. 36:198-202? Beak, J.Y. et al, 2008 Nucl. Acids Res. 36:1690-1702? Bauer B et al, 2008 J. Cerebral Blood Flow Metab 28:1222-1234? Bauer B et al, 2008 Mol. Pharm. 73: 329-41? Bastrikova N et al, 2008 Proc Natl Acad Sci USA 105:3123-7? Baozhong Zhao et al, 2008 Chem. Res. Toxicol. 21:1056-1063? Angers, M. et al, 2008 Biochem J. epub? Brehm, M.A. et al, 2007 Biochem J. 408:335-345 ? Brynczka, C. and Merrick, B.A. 2007 Neurochemical Research 32:1573-1585 ? Pei, Z. et al, 2007 Glia 55:1362-73 ? Smyth, J.T. et al, 2007 J. Cell Sci. 120:3672-3771

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES102485-01
Application #
7734572
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2008
Total Cost
$678,128
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Trebak, Mohamed; Lemonnier, Loic; DeHaven, Wayne I et al. (2009) Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch 457:757-69
DeHaven, Wayne I; Smyth, Jeremy T; Boyles, Rebecca R et al. (2008) Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem 283:19265-73
Putney, James W; Bird, Gary S (2008) Cytoplasmic calcium oscillations and store-operated calcium influx. J Physiol 586:3055-9
Smyth, Jeremy T; Dehaven, Wayne I; Bird, Gary S et al. (2008) Ca2+-store-dependent and -independent reversal of Stim1 localization and function. J Cell Sci 121:762-72
Vig, Monika; DeHaven, Wayne I; Bird, Gary S et al. (2008) Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol 9:89-96
Smyth, Jeremy T; DeHaven, Wayne I; Bird, Gary S et al. (2007) Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1. J Cell Sci 120:3762-71
Wedel, Barbara; Boyles, Rebecca R; Putney Jr, James W et al. (2007) Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. J Physiol 579:679-89