Abstract

Events leading to the onset of various ocular complications are being investigated. Specific studies include the role of enzymes aldose reductase and aldehyde reductase in the onset and progression of retinopathy, cataract, keratopathy, pupil function changes, and iris and ciliary process structure changes associated with diabetes and galactosemia. In addition, methods for either delaying or preventing the onset and progression of these complications through the pharmacological control of these enzymes are being developed. Also being studied are events leading to the formation of several types of cataracts, as well as methods for controlling the onset of these cataracts through pharmacological intervention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000003-21
Application #
3777596
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Schlitzer, M; Rodriguez, L; Kador, P F (2001) Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements. J Pharm Pharmacol 53:831-9
Murata, M; Ohta, N; Sakurai, S et al. (2001) The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem Biol Interact 130-132:617-25
Mizoguchi, T; Maeda, I; Yagi, K et al. (2001) Effect of bovine small intestine thioredoxin on aldose reductase activity. Chem Biol Interact 130-132:609-15
Sugiyama, K; Chen, Z; Lee, Y S et al. (2000) Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochem Pharmacol 59:329-36
Murata, M; Kador, P F; Sato, S (2000) Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. J Ocul Pharmacol Ther 16:383-91
Kador, P F; Lee, J W; Fujisawa, S et al. (2000) Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J Ocul Pharmacol Ther 16:149-60
Lizak, M J; Datiles, M B; Aletras, A H et al. (2000) MRI of the human eye using magnetization transfer contrast enhancement. Invest Ophthalmol Vis Sci 41:3878-81
Mizoguchi, T; Maeda, I; Yagi, K et al. (1999) Formation of lens aldose reductase mixed disulfides with GSH by UV irradiation and its proteolysis by lens calpain. Adv Exp Med Biol 463:481-6
Sato, S; Secchi, E F; Lizak, M J et al. (1999) Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells. Invest Ophthalmol Vis Sci 40:697-704
Secchi, E F; Lizak, M J; Sato, S et al. (1999) 3-Fluoro-3-deoxy-D-galactose: a new probe for studies on sugar cataract. Curr Eye Res 18:277-82

Showing the most recent 10 out of 18 publications