Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000003-24
Application #
2711650
Study Section
Special Emphasis Panel ( LOT)
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
1996
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Schlitzer, M; Rodriguez, L; Kador, P F (2001) Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements. J Pharm Pharmacol 53:831-9
Murata, M; Ohta, N; Sakurai, S et al. (2001) The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem Biol Interact 130-132:617-25
Mizoguchi, T; Maeda, I; Yagi, K et al. (2001) Effect of bovine small intestine thioredoxin on aldose reductase activity. Chem Biol Interact 130-132:609-15
Sugiyama, K; Chen, Z; Lee, Y S et al. (2000) Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochem Pharmacol 59:329-36
Murata, M; Kador, P F; Sato, S (2000) Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. J Ocul Pharmacol Ther 16:383-91
Kador, P F; Lee, J W; Fujisawa, S et al. (2000) Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J Ocul Pharmacol Ther 16:149-60
Lizak, M J; Datiles, M B; Aletras, A H et al. (2000) MRI of the human eye using magnetization transfer contrast enhancement. Invest Ophthalmol Vis Sci 41:3878-81
Sato, S; Sugiyama, K; Lee, Y S et al. (1999) Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Exp Eye Res 68:601-8
Sugiyama, K; Wang, T C; Simpson, J T et al. (1999) Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone. Drug Metab Dispos 27:60-7
Ohta, N; Tsai, J Y; Secchi, E F et al. (1999) Neutrophils in galactose-fed dogs: suppressed apoptosis and increased adhesion to retinal capillary endothelial cells. J Diabetes Complications 13:151-8

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