Internal and external messengers have been studied which code for aspects of growth, development and function of normal retinal cells and also which affect differentiation of retinoblastoma cells in culture. Insulin receptors are present in high concentration in normal retinal cells and in retinoblastoma cells indicating a role for insulin in retinal function. Also, extracellular matrix components such as laminin have been found to affect differentiation of cultured human retinoblastoma cells.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000124-08
Application #
3941637
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code