Molecular Genetics of Early Eye Development

Tomarev, Stanislav I.

Abstract

The role of several genes involved in eye development and function was studied. The involvement of Prox 1 gene in eye regression and sensory organ compensation was investigated in collaboration with Dr. W. Jeffery (University of Maryland). The results suggest that Prox 1 is not directly involved in cavefish eye regression. However, Prox 1 may have a role in compensation for blindness by enhancing the gustatory and lateral line sensory organs during cavefish development. The full structure of previously identified human Prox 2 gene was elucidated. While Prox 1 and Prox 2 proteins are only 40% identical, their homeodomains show 82% identity. The role of Eya2 gene in chicken limb bud development was studied in collaboration with Dr. C. Tabin (Harvard University). It was shown that Eya2 physically interacts with Dach2 and Six 1, and might be involved in the regulation of myogenesis. - eye, development, homeobox, prox1, lens, Eya2, chicken, Prox 2, cavefish, myogenesis

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Eye Institute (NEI)
• Type: Intramural Research (Z01)
• Project #: 1Z01EY000311-04
• Application #: 6290139
• Study Section: Special Emphasis Panel (LMDB)
• Support Year: 4
• Fiscal Year: 1999

Institution

• Name: U.S. National Eye Institute
• Country: United States

Publications

Nakaya, Naoki; Sultana, Afia; Munasinghe, Jeeva et al. (2013) Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Exp Neurol 250:205-18

Nakaya, Naoki; Lee, Hee-Sheung; Takada, Yuichiro et al. (2008) Zebrafish olfactomedin 1 regulates retinal axon elongation in vivo and is a modulator of Wnt signaling pathway. J Neurosci 28:7900-10

Lee, Hee-Sheung; Tomarev, Stanislav I (2007) Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells. Exp Cell Res 313:98-108

Galeeva, A; Treuter, E; Tomarev, S et al. (2007) A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Neuroscience 146:604-16

Nakaya, Naoki; Tomarev, Stanislav (2007) Expression patterns of alternative transcripts of the zebrafish olfactomedin 1 genes. Gene Expr Patterns 7:723-9

Wilting, Jorg; Aref, Yama; Huang, Ruijin et al. (2006) Dual origin of avian lymphatics. Dev Biol 292:165-73

Grinchuk, Oleg; Kozmik, Zbynek; Wu, Xiaofang et al. (2005) The Optimedin gene is a downstream target of Pax6. J Biol Chem 280:35228-37

Reis, Rui M; Reis-Filho, Jorge S; Longatto Filho, Adhemar et al. (2005) Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. Pathol Res Pract 201:771-6

Murphy, Patrick J M; Morishima, Yoshihiro; Kovacs, Jeffrey J et al. (2005) Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem 280:33792-9

Steffensen, Knut R; Holter, Elin; Bavner, Ann et al. (2004) Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Rep 5:613-9