The Vaginal Infections and Prematurity (VIP) Study, jointly sponsored by NICHD and NIAID, is a prospective study designed to investigate the relationship between genital tract colonization with various microorganisms and the subsequent development of preterm birth. It also incorporates a clinical trial of erythromycin to prevent preterm birth among women colonized with U. urealyticum, C. trachomatis, and group B streptococcus. In addition, the VIP collected a wealth of additional data on a variety of factors possibly linked to pregnancy outcome. This project will analyze these factors. Questions addressed to date include the predictive value of vaginal Gram stain in the identification of group B streptococcus, the descriptive epidemiology of group B streptococcal carriage, and the relationship between reported physical activity and preterm birth.
|Carey, J Christopher; Klebanoff, Mark A (2005) Is a change in the vaginal flora associated with an increased risk of preterm birth? Am J Obstet Gynecol 192:1341-6; discussion 1346-7|
|Fiscella, Kevin; Klebanoff, Mark A (2004) Are racial differences in vaginal pH explained by vaginal flora? Am J Obstet Gynecol 191:747-50|
|Carey, J Christopher; Klebanoff, Mark A; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2003) What have we learned about vaginal infections and preterm birth? Semin Perinatol 27:212-6|
|Klebanoff, Mark A; Guise, Jeanne-Marie; Carey, J Christopher (2003) Treatment recommendations for bacterial vaginosis in pregnant women. Clin Infect Dis 36:1630-1; author reply 1631-2|