Analyses of Data From the Collaborative Perinatal Project

Klebanoff, Mark A.

Abstract

The Collaborative Perinatal Project (CPP) represents a rich data set for the investigation of a variety of topics related to maternal and child health. Recent projects have begun to utilize the serum collected from pregnant women and neonates as part of that study which, along with the data collected as part of the original study and subsequently collected, provide a unique resource for the conduct of maternal and child health epidemiologic research. The project in FY 99 is investigating perinatal risk factors for the subsequent development of schizophrenia in adult life. In this project, 52 individuals from the Providence, Rhode Island site of the CPP who developed schizophrenia as adults were identified and matched to 104 cohort members who did not have any major psychiatric pathology. In addition, similar tracing was begun on members of the Boston, MA Cohort. Evidence of viral infection, immune activation, and hypoxia is being sought in both their stored umbilical cord serum, and in their mother's serum obtained during pregnancy.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Intramural Research (Z01)
• Project #: 1Z01HD000383-10
• Application #: 6432516
• Study Section: (OD)
• Support Year: 10
• Fiscal Year: 2000

Institution

• Name: U.S. National Inst/Child Hlth/Human Dev
• Country: United States

Publications

Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95

Klebanoff, Mark A; Zhang, Jun; Zhang, Cuilin et al. (2009) Maternal serum theobromine and the development of preeclampsia. Epidemiology 20:727-32

Klebanoff, Mark A (2009) The Collaborative Perinatal Project: a 50-year retrospective. Paediatr Perinat Epidemiol 23:2-8

Ness, Roberta B; Zhang, Jun; Bass, Debra et al. (2008) Interactions between smoking and weight in pregnancies complicated by preeclampsia and small-for-gestational-age birth. Am J Epidemiol 168:427-33

Zhang, Yawei; Graubard, Barry I; Longnecker, Matthew P et al. (2007) Maternal hormone levels and perinatal characteristics: implications for testicular cancer. Ann Epidemiol 17:85-92

Bodnar, Lisa M; Catov, Janet M; Klebanoff, Mark A et al. (2007) Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy. Epidemiology 18:234-9

Ness, Roberta B; Bass, Debra; Hill, Lyndon et al. (2007) Diagnostic test characteristics of placental weight in the prediction of small-for-gestational-age neonates. J Reprod Med 52:793-800

Johnson, Kimberly J; Spector, Logan G; Klebanoff, Mark A et al. (2007) Childhood cancer and birthmarks in the Collaborative Perinatal Project. Pediatrics 119:e1088-93

Pierik, Frank H; Klebanoff, Mark A; Brock, John W et al. (2007) Maternal pregnancy serum level of heptachlor epoxide, hexachlorobenzene, and beta-hexachlorocyclohexane and risk of cryptorchidism in offspring. Environ Res 105:364-9

Hemachandra, Anusha H; Howards, Penelope P; Furth, Susan L et al. (2007) Birth weight, postnatal growth, and risk for high blood pressure at 7 years of age: results from the Collaborative Perinatal Project. Pediatrics 119:e1264-70