Data from The Collaborative Perinatal Project

Klebanoff, Mark A.

Abstract

The Collaborative Perinatal Project (CPP) is a rich data set for the investigation of a variety of topics related to maternal and child health. Recent projects have also begun to utilize the serum collected from pregnant women and their neonates as part of this study, which, along with data collected as for the original study and subsequently, provides a unique resource. Areas investigated in FY 01 include studies of hypertensive disorders of pregnancy, the association between birth weight and blood pressure at age seven in twins, risk factors for infantile cataract, and perinatal risk factors for subsequent adult-onset schizophrenia. In the latter study, over 100 individuals from the Providence and Boston sites of the CPP who developed schizophrenia as adults were identified and matched to over 200 cohort members who did not have significant psychiatric pathology. Evidence of hypoxia, viral infection, and immune activation was sought in maternal and umbilical cord serum. Planned analysis for 2002 include maternal seroconversion to SV-40 virus during pregnancy (a result of contaminated Salk polio vaccine before 1963) as a risk factor for childhood cancer.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Intramural Research (Z01)
• Project #: 1Z01HD000383-11
• Application #: 6541114
• Study Section: (SPR)
• Support Year: 11
• Fiscal Year: 2001

Institution

• Name: U.S. National Inst/Child Hlth/Human Dev
• Country: United States

Publications

Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95

Klebanoff, Mark A; Zhang, Jun; Zhang, Cuilin et al. (2009) Maternal serum theobromine and the development of preeclampsia. Epidemiology 20:727-32

Klebanoff, Mark A (2009) The Collaborative Perinatal Project: a 50-year retrospective. Paediatr Perinat Epidemiol 23:2-8

Ness, Roberta B; Zhang, Jun; Bass, Debra et al. (2008) Interactions between smoking and weight in pregnancies complicated by preeclampsia and small-for-gestational-age birth. Am J Epidemiol 168:427-33

Ness, Roberta B; Bass, Debra; Hill, Lyndon et al. (2007) Diagnostic test characteristics of placental weight in the prediction of small-for-gestational-age neonates. J Reprod Med 52:793-800

Johnson, Kimberly J; Spector, Logan G; Klebanoff, Mark A et al. (2007) Childhood cancer and birthmarks in the Collaborative Perinatal Project. Pediatrics 119:e1088-93

Pierik, Frank H; Klebanoff, Mark A; Brock, John W et al. (2007) Maternal pregnancy serum level of heptachlor epoxide, hexachlorobenzene, and beta-hexachlorocyclohexane and risk of cryptorchidism in offspring. Environ Res 105:364-9

Hemachandra, Anusha H; Howards, Penelope P; Furth, Susan L et al. (2007) Birth weight, postnatal growth, and risk for high blood pressure at 7 years of age: results from the Collaborative Perinatal Project. Pediatrics 119:e1264-70

Zhang, Yawei; Graubard, Barry I; Longnecker, Matthew P et al. (2007) Maternal hormone levels and perinatal characteristics: implications for testicular cancer. Ann Epidemiol 17:85-92

Bodnar, Lisa M; Catov, Janet M; Klebanoff, Mark A et al. (2007) Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy. Epidemiology 18:234-9