Steroid Hormone Action In Female Reproduction

Nieman, Lynnette K.

Abstract

This project focuses on leiomyomata (fibroids) and examines factors related to their pathogenesis, diagnosis and/or potential treatment. Ongoing work seeks to evaluate the utility of the progesterone response modulator CDB2914 as a treatment of fibroids. We previously investigated the effect of single doses of the agent on the menstrual cycle in women, and showed that doses of 100 or 200 mg retard folliculogenesis and precipitate menses, in the follicular and luteal phase respectively. A recently completed study showed reduction in fibroid size in women receiving CDB 2914 at a daily dose of 10 or 20 mg for three months, as compared to women receiving placebo. ? ? An ongoing randomized double-blind clinical trial evaluates whether CDB 2914 has additional inhibitory effect during a six month treatment, and also evaluates the duration of the inhibition of growth after treatment is discontinued. We also are using gene arrays to evaluate the pathophysiology of leiomyomata.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Intramural Research (Z01)
• Project #: 1Z01HD000637-15
• Application #: 7734699
• Support Year: 15
• Fiscal Year: 2008
• Total Cost: $614,893

Institution

• Name: Eunice Kennedy Shriver National Institute of Child Health & Human Development
• Country: United States

Publications

Wei, Qingxiang; St Clair, J Benjamin; Fu, Teresa et al. (2009) Reduced expression of biomarkers associated with the implantation window in women with endometriosis. Fertil Steril 91:1686-91

Levens, Eric D; Potlog-Nahari, Clariss; Armstrong, Alicia Y et al. (2008) CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial. Obstet Gynecol 111:1129-36

Stegmann, Barbara J; Sinaii, Ninet; Liu, Shannon et al. (2008) Using location, color, size, and depth to characterize and identify endometriosis lesions in a cohort of 133 women. Fertil Steril 89:1632-6

Parker, Jason D; Leondires, Mark; Sinaii, Ninet et al. (2006) Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis. Fertil Steril 86:711-5

Hearns-Stokes, Rhonda; Mayers, Chantal; Zahn, Christopher et al. (2006) Expression of the proto-oncoprotein breast cancer nuclear receptor auxiliary factor (Brx) is altered in eutopic endometrium of women with endometriosis. Fertil Steril 85:63-70

Roca, Catherine A; Schmidt, Peter J; Deuster, Patricia A et al. (2005) Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression. J Clin Endocrinol Metab 90:4224-31

Rubinow, David R; Roca, Catherine A; Schmidt, Peter J et al. (2005) Testosterone suppression of CRH-stimulated cortisol in men. Neuropsychopharmacology 30:1906-12

Potlog-Nahari, Clariss; Stratton, Pamela; Winkel, Craig et al. (2004) Urine vascular endothelial growth factor-A is not a useful marker for endometriosis. Fertil Steril 81:1507-12

Potlog-Nahari, Clariss; Feldman, Andrew L; Stratton, Pamela et al. (2004) CD10 immunohistochemical staining enhances the histological detection of endometriosis. Fertil Steril 82:86-92

Voutetakis, Antonis; Kok, Marc R; Zheng, Changyu et al. (2004) Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A 101:3053-8