This project investigates biobehavioral development through comparative longitudinal study of nonhuman primates, with special emphasis on characterizing individual differences among rhesus monkeys in their behavioral and physiological responses to mild environmental challenges and on determining the long-term developmental consequences for these individuals in different physical and social environments. During FY90 continued longitudinal study of genetic and environmental factors influencing response to challenge yielded findings that both broadened the scope of the phenomena and provided insight as to underlying mechanisms. A new technique for direct intraventricular peptide infusion permitted the assessment of changes in behavior and pituitary-adrenocortical activity in socially living rhesus monkeys following different doses of CRF and CRF anatagonists. Investigations of adolescent rhesus monkeys living in wild settings validated the relationship between individual differences in response to challenge and levels of adrenocortical activity and monoamine turnover previously reported for laboratory-housed adolescent monkeys. A second ongoing field study further related patterns of biobehavioral response to challenge to differential patterns of adolescent male emigration and mortality risk. Completion and staffing of a neonatal nursery permitted the initiation of a new set of studies focusing on rhesus monkey neonatal psychophysiological, neurochemical, attentional, and behavioral predictors of differential response to challenge later in life. Completion of new facilities for housing New World primates made it possible to establish a self-sufficient colony of Cebus apella and to begin parallel studies of factors influencing biobehavioral response to challenge in this primate species.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Barr, Christina S; Dvoskin, Rachel L; Gupte, Manisha et al. (2009) Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci U S A 106:14593-8
Cirulli, F; Laviola, G; Ricceri, L (2009) Risk factors for mental health: translational models from behavioural neuroscience. Neurosci Biobehav Rev 33:493-7
Dettmer, Amanda M; Ruggiero, Angela M; Novak, Melinda A et al. (2008) Surrogate mobility and orientation affect the early neurobehavioral development of infant rhesus macaques (Macaca mulatta). Dev Psychobiol 50:418-22
Schwandt, Melanie L; Barr, Christina S; Suomi, Stephen J et al. (2007) Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 31:228-37
Spinelli, Simona; Schwandt, Melanie L; Lindell, Stephen G et al. (2007) Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Dev Psychopathol 19:977-87
Howell, Sue; Westergaard, Greg; Hoos, Beth et al. (2007) Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques. Am J Primatol 69:851-65
Barr, Christina S; Schwandt, Melanie; Lindell, Stephen G et al. (2007) Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 64:369-76
Suomi, Stephen J (2006) Risk, resilience, and gene x environment interactions in rhesus monkeys. Ann N Y Acad Sci 1094:52-62
Lorenz, Joseph G; Long, Jeffrey C; Linnoila, Markku et al. (2006) Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 30:389-98
Ichise, Masanori; Vines, Douglass C; Gura, Tami et al. (2006) Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J Neurosci 26:4638-43

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