This project investigates primate biobehavioral development through comparative longitudinal studies of rhesus and capuchin monkeys, with special emphasis on characterizing individual patterns of differential behavioral and physiological responses to environmental novelty and challenge and on determining long-term developmental consequences for individuals of different genetic backgrounds reared in different physical and social environments. Research carried out during FY00 (a) characterized a polymorphism in the serotonin 1Db receptor gene (5-HT1Db) for rhesus monkeys, with allele frequencies of p=.82 and q=.18, respecively, in the LCE rhesus monkey colony; (b) demonstrated a predictive relationship between polymorphic status of the 5-HTT gene and measures of behavioral disturbance in 1-month-old rhesus monkey infants; (c) demonstrated significant interactions between 5-HTT polymorphisms and early rearing history for visual orienting capabilities, state control, and activity levels in rhesus monkey neonates; (d) using MRI scans, documented sex differences in total brain volume, but not in total body weight, in yearling rhesus monkeys; (e) characterized developmental changes in circadian rhythmicity of activity patterns in young rhesus monkeys; (f) disclosed a predictive relationship betweencerebrospinal fluid (CSF) concentrations of the primary central serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and measures of fearfulness and sociality in 1-month-old rhesus monkey infants; (g) characterized significant rearing condition differences in CSF 5-HIAA concentrations that remained stable for rhesus monkeys from infancy to adolescence; (h) documented rearing condition differences in CSF concentrations of corticotrophin releasing hormone (CRH) following a mild environmental challenge in rhesus monkey juveniles; (i) demonstrated that the CRH type 1 receptor antagonist analarmin suppresses hypothalamic-pituitary-adrenal (HPA) activity and behavioral manifestations of fearfulness in adult male rhesus monkeys; and (j) documented predictive relationships between HPA reactivity and a variety of specific measures of social behavior and environmental exploration in capuchin monkey juveniles that parallelled previous findings in rhesus monkeys, despite major differences between the two species in overall rates of social activity and in social group structure and dynamics.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
U.S. National Inst/Child Hlth/Human Dev
United States
Zip Code
Barr, Christina S; Dvoskin, Rachel L; Gupte, Manisha et al. (2009) Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci U S A 106:14593-8
Cirulli, F; Laviola, G; Ricceri, L (2009) Risk factors for mental health: translational models from behavioural neuroscience. Neurosci Biobehav Rev 33:493-7
Dettmer, Amanda M; Ruggiero, Angela M; Novak, Melinda A et al. (2008) Surrogate mobility and orientation affect the early neurobehavioral development of infant rhesus macaques (Macaca mulatta). Dev Psychobiol 50:418-22
Schwandt, Melanie L; Barr, Christina S; Suomi, Stephen J et al. (2007) Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 31:228-37
Spinelli, Simona; Schwandt, Melanie L; Lindell, Stephen G et al. (2007) Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Dev Psychopathol 19:977-87
Howell, Sue; Westergaard, Greg; Hoos, Beth et al. (2007) Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques. Am J Primatol 69:851-65
Barr, Christina S; Schwandt, Melanie; Lindell, Stephen G et al. (2007) Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 64:369-76
Suomi, Stephen J (2006) Risk, resilience, and gene x environment interactions in rhesus monkeys. Ann N Y Acad Sci 1094:52-62
Lorenz, Joseph G; Long, Jeffrey C; Linnoila, Markku et al. (2006) Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 30:389-98
Ichise, Masanori; Vines, Douglass C; Gura, Tami et al. (2006) Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J Neurosci 26:4638-43

Showing the most recent 10 out of 43 publications