This group is studying the problem of how organisms sense a change in their environment and transduce the environmental signal into a change in gene expression and morphology. It was found that OxyR, a regulator of hydrogen peroxide-inducible genes in bacteria, is both the sensor and transducer of an oxidative stress signal. Oxidation of the OxyR protein beings about a conformational change which allows OxyR to activate transcription of defense genes. This group has also begun to study how Arabidopsis plants respond to light. Mutants that are no longer responsive to blue light are being isolated in order to define components in the blue light signal transduction pathway.
| Hemm, Matthew R; Paul, Brian J; Schneider, Thomas D et al. (2008) Small membrane proteins found by comparative genomics and ribosome binding site models. Mol Microbiol 70:1487-501 |
| Kawano, Mitsuoki; Aravind, L; Storz, Gisela (2007) An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol 64:738-54 |
| Wang, Xunde; Mukhopadhyay, Partha; Wood, Matthew J et al. (2006) Mutational analysis to define an activating region on the redox-sensitive transcriptional regulator OxyR. J Bacteriol 188:8335-42 |
| Tjaden, Brian; Goodwin, Sarah S; Opdyke, Jason A et al. (2006) Target prediction for small, noncoding RNAs in bacteria. Nucleic Acids Res 34:2791-802 |
| Hu, Zonglin; Zhang, Aixia; Storz, Gisela et al. (2006) An antibody-based microarray assay for small RNA detection. Nucleic Acids Res 34:e52 |
| Storz, G; Opdyke, J A; Wassarman, K M (2006) Regulating bacterial transcription with small RNAs. Cold Spring Harb Symp Quant Biol 71:269-73 |
| Storz, Gisela; Altuvia, Shoshy; Wassarman, Karen M (2005) An abundance of RNA regulators. Annu Rev Biochem 74:199-217 |
| Kawano, Mitsuoki; Reynolds, April A; Miranda-Rios, Juan et al. (2005) Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Nucleic Acids Res 33:1040-50 |
| Kawano, Mitsuoki; Storz, Gisela; Rao, B Sridhar et al. (2005) Detection of low-level promoter activity within open reading frame sequences of Escherichia coli. Nucleic Acids Res 33:6268-76 |
| Wood, Matthew J; Storz, Gisela (2005) Oxygen, metabolism, and gene expression: the T-Rex connection. Structure 13:2-4 |
Showing the most recent 10 out of 33 publications
