This group studies how organisms sense environmental signals and transduce the signals into changes in gene expression and cell physiology. The group has continued their characterization of the two regulators central to the Escherichia coli response to oxidative stress: OxyR, a 34 kDa transcriptional regulator whose activity is modulated by oxidation and reduction, and OxyS, a novel 109 nucleotide RNA that acts as an activator and repressor of gene expression. In addition to studying the mechanism of OxyS RNA action, the group has begun to characterize the functions of other small, untranslated RNAs in E. coli. The group recently discovered that the 6S RNA associates with and modulates RNA polymerase. The group also has carried out genetic screens and whole genome expression analysis to determine what regulators are important to the Saccharomyces cerevisiae response to hydrogen peroxide.
| Hemm, Matthew R; Paul, Brian J; Schneider, Thomas D et al. (2008) Small membrane proteins found by comparative genomics and ribosome binding site models. Mol Microbiol 70:1487-501 |
| Kawano, Mitsuoki; Aravind, L; Storz, Gisela (2007) An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol 64:738-54 |
| Wang, Xunde; Mukhopadhyay, Partha; Wood, Matthew J et al. (2006) Mutational analysis to define an activating region on the redox-sensitive transcriptional regulator OxyR. J Bacteriol 188:8335-42 |
| Tjaden, Brian; Goodwin, Sarah S; Opdyke, Jason A et al. (2006) Target prediction for small, noncoding RNAs in bacteria. Nucleic Acids Res 34:2791-802 |
| Hu, Zonglin; Zhang, Aixia; Storz, Gisela et al. (2006) An antibody-based microarray assay for small RNA detection. Nucleic Acids Res 34:e52 |
| Storz, G; Opdyke, J A; Wassarman, K M (2006) Regulating bacterial transcription with small RNAs. Cold Spring Harb Symp Quant Biol 71:269-73 |
| Storz, Gisela; Altuvia, Shoshy; Wassarman, Karen M (2005) An abundance of RNA regulators. Annu Rev Biochem 74:199-217 |
| Kawano, Mitsuoki; Reynolds, April A; Miranda-Rios, Juan et al. (2005) Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Nucleic Acids Res 33:1040-50 |
| Kawano, Mitsuoki; Storz, Gisela; Rao, B Sridhar et al. (2005) Detection of low-level promoter activity within open reading frame sequences of Escherichia coli. Nucleic Acids Res 33:6268-76 |
| Wood, Matthew J; Storz, Gisela (2005) Oxygen, metabolism, and gene expression: the T-Rex connection. Structure 13:2-4 |
Showing the most recent 10 out of 33 publications
