(1)For the identification of selenium-modified bases in tRNAs, 5-carboethoxy- and 5-carboethoxymethyl-2-selenouracils were synthesized and characterized. (2)In order to gain insight into the biosynthetic steps for seleno-tRNAs, chemical activation of the sulfur function in 2-thiouracil derivatives was investigated.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL000206-31
Application #
3878874
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
31
Fiscal Year
1990
Total Cost
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code