Abstract

The structure of a new maltose phosphate arising from the action of oral bacteria has been elucidated and partially synthesized. A substance present in the bedding of hamsters used in supplying blood to malaria mosquitos has been found to be fatal to the mosquitos. Investigations using solvent partition and GC-MS are underway to determine its nature and the nature of the compound responsible for exflagellation in Anopheles species. A possible novel function for RNA has been found: the polymerization of macrocyclic lactones used by Colletes thoracicus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL001003-21
Application #
3779520
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lindh, Rebecka; Ahmad, Faiyaz; Resjo, Svante et al. (2007) Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B. Biochim Biophys Acta 1773:584-92
Ludwig, Joseph A; Szakacs, Gergely; Martin, Scott E et al. (2006) Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Res 66:4808-15
Davis, David A; Singer, Kathleen E; De La Luz Sierra, Maria et al. (2005) Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. Blood 105:4561-8
Goren, Mayer B; Sokoloski, Edward A; Fales, Henry M (2005) 2-Methyl-(1Z,3E)-butadiene-1,3,4-tricarboxylic acid, ""isoprenetricarboxylic acid"". J Org Chem 70:7429-31
Boja, Emily S; Hoodbhoy, Tanya; Garfield, Mark et al. (2005) Structural conservation of mouse and rat zona pellucida glycoproteins. Probing the native rat zona pellucida proteome by mass spectrometry. Biochemistry 44:16445-60
Zhao, Hongtao; Joseph, Joy; Fales, Henry M et al. (2005) Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A 102:5727-32
Che, Magnus M; Boja, Emily S; Yoon, Hye-Young et al. (2005) Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Cell Signal 17:1276-88
Sun, G; Ma, Y; Gao, X et al. (2004) Method for isolating tight-binding inhibitors of rat lens aldose reductase. Exp Eye Res 79:919-26
De La Luz Sierra, Maria; Yang, Fuquan; Narazaki, Masashi et al. (2004) Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood 103:2452-9
Jeong, Woojin; Chang, Tong-Shin; Boja, Emily S et al. (2004) Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. J Biol Chem 279:3151-9

Showing the most recent 10 out of 29 publications