Ventilator-Associated Pneumonia. Bactericidal Trachea

Kolobow, Theodor

Abstract

1. We have previously developed a method to totally clean the lumen of the tracheal tube in intubated sheep thorough the use of a catheter tip mounted inflatable balloon, provided with two """"""""Shaving Rings""""""""; upon inflation and retrieval of the Mucus Shaver, all mucus within the tracheal tube is removed in one sweep. 2. Now undergoing late stage test/evaluation is a novel system that, when implemented, is capable to maintain the tracheal tube, and the trachea free of mucus, and free of bacterial colonization; with no need for tracheal, or tracheal tube suctioning. 3. Based on above studies, and our preceeding studies, a clinical study is to be conducted headed by a former Visiting Fellow (Dr. Lorenzo Berra), in collaboration with PCCM, to evaluate clinical benefits of 1.The mucus shaver and 2. Tracheal tubes coated with silver sulfadiazine in polyhurethane. Such clinical protocol has been approved by the IRB of the participating hospital administration in Italy, and by the NHLBI IRB. The patient population is to consist of both patients in the medical ICU; and cardiosurgical patients

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Intramural Research (Z01)
• Project #: 1Z01HL001404-35
• Application #: 6966902
• Study Section: (PCAD)
• Support Year: 35
• Fiscal Year: 2004

Institution

• Name: U.S. National Heart Lung and Blood Inst
• Country: United States

Publications

Rezoagli, Emanuele; Zanella, Alberto; Cressoni, Massimo et al. (2017) Pathogenic Link Between Postextubation Pneumonia and Ventilator-Associated Pneumonia: An Experimental Study. Anesth Analg 124:1339-1346

Li Bassi, Gianluigi; Berra, Lorenzo; Kolobow, Theodor (2007) Silver-coated endotracheal tubes: is the bactericidal effect time limited? Crit Care Med 35:986;author reply 987

Parravicini, Elvira; Baccarelli, Andrea; Wung, Jen Tien et al. (2007) A comparison of a new, ultrathin-walled two-stage twin endotracheal tube and a conventional endotracheal tube in very premature infants with respiratory distress syndrome: a pilot study. Am J Perinatol 24:117-22

Li Bassi, Gianluigi; Curto, Francesco; Zanella, Alberto et al. (2007) A 72-hour study to test the efficacy and safety of the ""Mucus Slurper"" in mechanically ventilated sheep. Crit Care Med 35:906-11

Kolobow, Theodor; Berra, Lorenzo; Li Bassi, Gianluigi et al. (2005) Novel system for complete removal of secretions within the endotracheal tube: the Mucus Shaver. Anesthesiology 102:1063-5

Berra, Lorenzo; De Marchi, Lorenzo; Panigada, Mauro et al. (2004) Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med 32:2071-8

Kolobow, Theodor (2004) The artificial lung: the past. A personal retrospective. ASAIO J 50:xliii-xlviii

Kolobow, Theodor; Berra, Lorenzo; DeMarchi, Lorenzo et al. (2004) Ultrathin-wall, two-stage, twin endotracheal tube: a tracheal tube with minimal resistance and minimal dead space for use in newborn and infant patients. Pediatr Crit Care Med 5:379-83

Berra, Lorenzo; De Marchi, Lorenzo; Yu, Zu-Xi et al. (2004) Endotracheal tubes coated with antiseptics decrease bacterial colonization of the ventilator circuits, lungs, and endotracheal tube. Anesthesiology 100:1446-56

Kolobow, Theodor (2004) Volutrauma, barotrauma, and ventilator-induced lung injury: lessons learned from the animal research laboratory. Crit Care Med 32:1961-2