New imaging techniques

Wen, Han

Abstract

Our lab has applied a high-power MRI technique called DENSE to image heart wall and carotid artery wall motion in detail. DENSE stands for Displacement ENcoding with Stimulated Echo and is pioneered in our lab. We successfully developed this year the scan protocol and data processing software for heart and blood vessel wall strain and motion mapping. We developed an image processing software package that is able to generate within 10 minutes segmental contractile strain curves and various functional maps of the myocardial wall from DENSE MRI data. In collaboration with clinical sites this technique has been used in patients of various heart diseases.? We also validated our detailed vessel wall strain measurements with hand-traced contours of the lumen of the carotid artery in normal volunteers. Since the stiffness of the arterial wall is an indication of vascular diseases and is related to the formation of atherosclerotic lesions, this technique holds potential in the diagnosis and management of these diseases.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Intramural Research (Z01)
• Project #: 1Z01HL004606-10
• Application #: 7321614
• Study Section: (LCE)
• Support Year: 10
• Fiscal Year: 2006

Institution

• Name: U.S. National Heart Lung and Blood Inst
• Country: United States

Publications

Stein, Ashley F; Ilavsky, Jan; Kopace, Rael et al. (2010) Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique. Opt Express 18:13271-8

Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2009) Fourier X-ray scattering radiography yields bone structural information. Radiology 251:910-8

Wen, Han; Marsolo, Keith A; Bennett, Eric E et al. (2008) Adaptive postprocessing techniques for myocardial tissue tracking with displacement-encoded MR imaging. Radiology 246:229-40

Lin, Alexander P; Bennett, Eric; Wisk, Lauren E et al. (2008) Circumferential strain in the wall of the common carotid artery: comparing displacement-encoded and cine MRI in volunteers. Magn Reson Med 60:8-13

Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2008) Spatial harmonic imaging of X-ray scattering--initial results. IEEE Trans Med Imaging 27:997-1002

Jobsis, Paul D; Ashikaga, Hiroshi; Wen, Han et al. (2007) The visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle. Am J Physiol Heart Circ Physiol 293:H3379-87

Rodriguez, Ignacio; Ennis, Daniel B; Wen, Han (2006) Noninvasive measurement of myocardial tissue volume change during systolic contraction and diastolic relaxation in the canine left ventricle. Magn Reson Med 55:484-90

Vignaud, Alexandre; Rodriguez, Ignacio; Ennis, Daniel B et al. (2006) Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI. Magn Reson Med 55:725-30

Derbyshire, J A; Herzka, D A; McVeigh, E R (2005) S5FP: spectrally selective suppression with steady state free precession. Magn Reson Med 54:918-28

Wen, Han; Bennett, Eric; Epstein, Neal et al. (2005) Magnetic resonance imaging assessment of myocardial elastic modulus and viscosity using displacement imaging and phase-contrast velocity mapping. Magn Reson Med 54:538-48