Abstract

As a continuation of the work in MR imaging of cardiac function, we performed patient tests comparing displacement-encoded MRI assessment (DENSE) with echo-cardiography assessment in collaboration with two clinical groups, and showed that the new MRI assessment significantly improves the sensitivity in detecting abnormal function.? In a related project we began to combine cardiac perfusion and function imaging and obtained first results in a pig ischemia model. ? Using a similar technique, we finished the first validation study in humans on the carotid artery regional compliance pattern. This serves as the basis to look at the relationship between regional compliance distribution and atherosclerosis.? In the area of x-ray imaging, we constructed a benchtop scanner of a new technique that relates the image contrast to microscopic structures, and obtained first data demonstrating the principle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL004606-12
Application #
7734998
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2008
Total Cost
$1,587,249
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Stein, Ashley F; Ilavsky, Jan; Kopace, Rael et al. (2010) Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique. Opt Express 18:13271-8
Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2009) Fourier X-ray scattering radiography yields bone structural information. Radiology 251:910-8
Wen, Han; Marsolo, Keith A; Bennett, Eric E et al. (2008) Adaptive postprocessing techniques for myocardial tissue tracking with displacement-encoded MR imaging. Radiology 246:229-40
Lin, Alexander P; Bennett, Eric; Wisk, Lauren E et al. (2008) Circumferential strain in the wall of the common carotid artery: comparing displacement-encoded and cine MRI in volunteers. Magn Reson Med 60:8-13
Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2008) Spatial harmonic imaging of X-ray scattering--initial results. IEEE Trans Med Imaging 27:997-1002
Jobsis, Paul D; Ashikaga, Hiroshi; Wen, Han et al. (2007) The visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle. Am J Physiol Heart Circ Physiol 293:H3379-87
Rodriguez, Ignacio; Ennis, Daniel B; Wen, Han (2006) Noninvasive measurement of myocardial tissue volume change during systolic contraction and diastolic relaxation in the canine left ventricle. Magn Reson Med 55:484-90
Vignaud, Alexandre; Rodriguez, Ignacio; Ennis, Daniel B et al. (2006) Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI. Magn Reson Med 55:725-30
Derbyshire, J A; Herzka, D A; McVeigh, E R (2005) S5FP: spectrally selective suppression with steady state free precession. Magn Reson Med 54:918-28
Wen, Han; Bennett, Eric; Epstein, Neal et al. (2005) Magnetic resonance imaging assessment of myocardial elastic modulus and viscosity using displacement imaging and phase-contrast velocity mapping. Magn Reson Med 54:538-48

Showing the most recent 10 out of 22 publications