We have continued to explore the role that reactive oxygen species (ROS)play in signal transduction pathways. We have shown that a variety of growth factors and cytokines induce the generation of ROS following ligand binding. Our studies suggest that the pathway leading to ROS generation involves the activation of the small GTP-binding proteins ras and rac1. This has led us to explore fully the role of these proteins, and in particular, their role in vascular biology. We have also explored the role that ROS play in apoptosis, and more recently in replicative senescence. Our current focus is on how small GTPases regulate the cellular redox state and the identification of protein targets of oxidants. In the last year we have been able to demonstrate that inhibition of rac proteins by expression of a dominant negative form of rac1, inhibits cell death that occurs following hypoxic/reoxygenation (Kim, et al. J. Clin. Invest., 1998, 101:1821-1826). Similarly, we have shown that in normal cells, expression of an activated ras gene induces senescence by a redox-dependent pathway (Lee, et al., J. Biol. Chem., submitted). We have also explored the role of reactive oxygen species in cardiac myocyte apoptosis (Tanaka, et al., J. Biol. Chem., 1998; 273:25922-25928). These results, along with ongoing studies will hopefully delineate a role for oxidant-dependent signal transduction.
| Finkel, Toren (2012) Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis. Cell Stem Cell 11:287-8 |
| Finkel, Toren; Quyyumi, Arshed A (2011) Genetic links between circulating cells and cardiovascular risk. Circ Cardiovasc Genet 4:218-20 |
| Lee, In Hye; Finkel, Toren (2009) Regulation of autophagy by the p300 acetyltransferase. J Biol Chem 284:6322-8 |
| Finkel, Toren; Hwang, Paul M (2009) The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition. Proc Natl Acad Sci U S A 106:11825-6 |
| Schieke, Stefan M; Finkel, Toren (2007) TOR and aging: less is more. Cell Metab 5:233-5 |
| Song, Shiwei; Finkel, Toren (2007) GAPDH and the search for alternative energy. Nat Cell Biol 9:869-70 |
| Finkel, Toren; Serrano, Manuel; Blasco, Maria A (2007) The common biology of cancer and ageing. Nature 448:767-74 |
| Cheung, Kevin J; Tzameli, Iphigenia; Pissios, Pavlos et al. (2007) Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 5:115-28 |
| Liu, Hongjun; Fergusson, Maria M; Castilho, Rogerio M et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317:803-6 |
| Khakoo, Aarif Y; Pati, Shibani; Anderson, Stasia A et al. (2006) Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 203:1235-47 |
Showing the most recent 10 out of 46 publications
