The administration of Interleukin-2 to patients with neoplasms is associated with the significant incidence of lymphocytic myocarditis, myocardial necrosis, and a vascular leak syndrome. In this project, a small animal model was developed to study these phenomena. The administration of IL-2 to rats produced lymphocytic myocarditis and myocardial necrosis with evidence of damage to the microvasculature and the myocytes by lymphokine-activated lymphocytes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL005215-01
Application #
3858172
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code