Mechanical and software improvements have been installed and tested on the dual cell Fourier transform ion cyclotron resonance spectrometer (FT-ICR) which have corrected many of the previously encountered problems. Laser desorption of polyethyleneglycol mixtures has been used to optimize ion optics and test ion trapping and transfer. Experiments to optimize sample sensitivity and detectability of neuropeptides are in progress. Collaborative studies on an organic ion microprobe to image the distribution of organic substances in tissue slices are continuing at Oak Ridge National Laboratory. Collaborative studies on element and nuclide selective analyses using a microwave reaction interface for gas chromatography-mass spectrometry are in progress at George Washington University.
| Nanavati, Dhaval; Austin, Daniel R; Catapano, Lisa A et al. (2011) The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome. J Neurochem 119:617-29 |
| Lockwich, Timothy; Pant, Jaya; Makusky, Anthony et al. (2008) Analysis of TRPC3-interacting proteins by tandem mass spectrometry. J Proteome Res 7:979-89 |
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| Tuo, Jingsheng; Bojanowski, Christine M; Zhou, Min et al. (2007) Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-36 |
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| Fujigaki, Hidetsugu; Saito, Kuniaki; Lin, Felix et al. (2006) Nitration and inactivation of IDO by peroxynitrite. J Immunol 176:372-9 |
| Zhuang, Zhengping; Huang, Steve; Kowalak, Jeff A et al. (2006) From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue. Int J Oncol 28:103-10 |
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