The motion of ions in a dual cell Fourier transform ion cyclotron resonancence spectrometer has been empirically measured and mathematically modeled in order to account for the analytical characteristics of this instrument. It is apparent that ions with significant kinetic energy cannot be successfully transferred between cells, and that additional focussing potentials are required to efficiently transfer laser desorbed ions. A continuous flow-fast atom bombardment inlet and ionization system on a tandem quadrupole mass spectrometer is being tested for repetitive analyses of polar organic compounds in biofluids. Preliminary data has been obtained for several neurotoxins and biogenic amine metabolites which indicate a minimum detectability of 1-10 ng/sample. The specificity and accuracy of this analytical instrument is presently being evaluated.
| Nanavati, Dhaval; Austin, Daniel R; Catapano, Lisa A et al. (2011) The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome. J Neurochem 119:617-29 |
| Lockwich, Timothy; Pant, Jaya; Makusky, Anthony et al. (2008) Analysis of TRPC3-interacting proteins by tandem mass spectrometry. J Proteome Res 7:979-89 |
| Turck, Christoph W; Falick, Arnold M; Kowalak, Jeffrey A et al. (2007) The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics 6:1291-8 |
| Tuo, Jingsheng; Bojanowski, Christine M; Zhou, Min et al. (2007) Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-36 |
| Arnott, David; Gawinowicz, Mary Ann; Kowalak, Jeffrey A et al. (2007) ABRF-PRG04: differentiation of protein isoforms. J Biomol Tech 18:124-34 |
| Glasker, Sven; Vortmeyer, Alexander O; Lonser, Russell R et al. (2006) Proteomic analysis of hemangioblastoma cyst fluid. Cancer Biol Ther 5:549-53 |
| Fujigaki, Hidetsugu; Saito, Kuniaki; Lin, Felix et al. (2006) Nitration and inactivation of IDO by peroxynitrite. J Immunol 176:372-9 |
| Zhuang, Zhengping; Huang, Steve; Kowalak, Jeff A et al. (2006) From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue. Int J Oncol 28:103-10 |
| Laurent, Claudine; Levinson, Douglas F; Schwartz, Sarah A et al. (2005) Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: A methodological study in postnatal and adult mouse. J Neurosci Res 81:613-21 |
| Xu, Ming; Geer, Lewis Y; Bryant, Stephen H et al. (2005) Assessing data quality of peptide mass spectra obtained by quadrupole ion trap mass spectrometry. J Proteome Res 4:300-5 |
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