Abstract

Previous work from this unit has focused on the cognitive and behavioral responses of Alzheimer patients to pharmacologic challenges with cholinergic and opiate antagonists. We observed that the dementia patients appeared more sensitive to these antagonists (scopolamine and naloxone) than previously reported in younger controls. This year, we have demonstrated that behavioral and cognitive responses (but not physiologic changes) following scopolamine are indeed greater at lower doses in Alzheimer patients than in age-matched controls, suggesting increased sensitivity in this population with known cholinergic deficits. We are now in the process of completing a similar comparison using naloxone in age-matched normal volunteers. Expanded studies of the cognitive, behavioral and neuroendocrine responses of Alzheimer patients to cholinergic agonists such as arecholine and nicotine are also underway.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH000339-05
Application #
3968425
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Huey, Edward D; Mirza, Nadeem; Putnam, Karen T et al. (2006) Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dement Geriatr Cogn Disord 22:48-53
Sunderland, Trey; Hampel, Harald; Takeda, Masatoshi et al. (2006) Biomarkers in the diagnosis of Alzheimer's disease: are we ready? J Geriatr Psychiatry Neurol 19:172-9
Cohen, Robert M; Szczepanik, Joanna; McManus, Michael et al. (2006) Hippocampal atrophy in the healthy is initially linear and independent of age. Neurobiol Aging 27:1385-94
Sunderland, Trey (2006) Modern diagnostic approaches in dementia: on the cusp of change. J Geriatr Psychiatry Neurol 19:123-4
Filbey, Francesca M; Holroyd, Tom; Carver, Frederick et al. (2005) A magnetoencephalography spatiotemporal analysis of neural activities during feature binding. Neuroreport 16:1747-52
Greenwood, P M; Sunderland, Trey; Putnam, Karen et al. (2005) Scaling of visuospatial attention undergoes differential longitudinal change as a function of APOE genotype prior to old age: results from the NIMH BIOCARD study. Neuropsychology 19:830-40
Buerger, Katharina; Teipel, Stefan J; Zinkowski, Raymond et al. (2005) Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment. Neurosci Lett 391:48-50
Sunderland, Trey; Gur, Raquel E; Arnold, Steven E (2005) The use of biomarkers in the elderly: current and future challenges. Biol Psychiatry 58:272-6
Sunderland, Trey (2005) Geriatric psychiatry: coming of age in America. Biol Psychiatry 58:263-4
Greenwood, P M; Lambert, Chantal; Sunderland, Trey et al. (2005) Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results From the National Institute of Mental Health's BIOCARD study. Neuropsychology 19:199-211

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