A pharmacologic challenge strategy in Alzheimer patients using cholinergic and non-cholinergic agents has been the focus of this unit for a number of years. We have previously documented that Alzheimer patients are behaviorally and cognitively more sensitive to acute anticholinergic blockade with intravenous scopolamine, suggesting increased functional sensitivity compared to age-matched controls. This year, we have shown that this increased sensitivity is not seen in geriatric depressed patients, another population frequently presenting with cognitive deficits but without documented central cholinergic pathology. This functional sensitivity to anticholinergic agents in dementia patients has potential therapeutic implications, and we are now exploring the sensitivity of this population to a series of cholinergic agonists, including arecoline and nicotine. Another major thrust of our unit has been the therapeutic usefulness of the selective monoamine oxidase inhibitor (MAOI), L-deprenyl, in dementia patients. Work from this last year has demonstrated that deprenyl has beneficial cognitive and behavioral effects in the Alzheimer population without serious side effects. In addition, study of the biochemical changes which accompany the use of this drug has been helpful in characterizing some of the possible mechanisms of action. While the therapeutic benefit was relatively small compared to the overall devastation of the illness, the positive effects were encouraging, and we are currently in the process of studying the longer-term effects of this drug in demented patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH000339-07
Application #
3944627
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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