Abstract

Tetrahydrobiopterin (BH4) biosynthesis has been shown to proceed through tetrahydro intermediates. The first tetrahydro intermediate has been shown to be 6-pyruvoyl-tetrahydropterin. The enzyme catalyzing the formation of this intermediate, 6-pyruvoyl-tetrahydropterin synthase, has been purified from brain and liver. Sepiapterin reductase catalyzes the last reaction in BH4 biosynthesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH001039-04
Application #
4696386
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Maceyka, Michael; Milstien, Sheldon; Spiegel, Sarah (2007) Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. Circ Res 100:7-9
Alvarez, Sergio E; Milstien, Sheldon; Spiegel, Sarah (2007) Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab 18:300-7
Oskeritzian, Carole A; Milstien, Sheldon; Spiegel, Sarah (2007) Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther 115:390-9
Payne, Shawn G; Oskeritzian, Carole A; Griffiths, Rachael et al. (2007) The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109:1077-85
Watterson, Kenneth R; Berg, Krystina M; Kapitonov, Dmitri et al. (2007) Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. FASEB J 21:2818-28
Le Stunff, Herve; Giussani, Paola; Maceyka, Michael et al. (2007) Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem 282:34372-80
Maceyka, Michael; Milstien, Sheldon; Spiegel, Sarah (2007) Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. Methods Enzymol 434:243-56
Mitra, Poulami; Payne, Shawn G; Milstien, Sheldon et al. (2007) A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. Methods Enzymol 434:257-64
Sankala, Heidi M; Hait, Nitai C; Paugh, Steven W et al. (2007) Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 67:10466-74
Spiegel, Sarah; Milstien, Sheldon (2007) Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem 282:2125-9

Showing the most recent 10 out of 56 publications